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Incorporation of in vitro enzyme data into the physiologically-based pharmacokinetic (PB-PK) model for methylene
R H Reitz1, A L Mendrala, C N Park
1Dow Chemical Company, Health and Environmental Sciences, Midland, MI 48674.
Toxicology Letters
|October 1, 1988
Abstract:
Physiologically-based pharmacokinetic (PB-PK) models provide a mechanism for reducing the uncertainty inherent in extrapolating the results of animal toxicity tests to man. This paper discusses a technique for incorporating data from in vitro studies of xenobiotic metabolism into in vivo PB-PK models. Methylene chloride is used as an example, and carcinogenic risk estimates incorporating PB-PK principles are presented.