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Updated: Jan 3, 2026

Describing a Transcription Factor Dependent Regulation of the MicroRNA Transcriptome
Published on: June 15, 2016
Role of MicroRNAs in the Regulation of Redox-Dependent Processes
E V Kalinina1, V I Ivanova-Radkevich2, N N Chernov2
1Peoples' Friendship University of Russia (RUDN University), Moscow, 117198, Russia. kalinina-ev@rudn.ru.
Abstract:
Cellular redox homeostasis involves a combination of redox processes and corresponding regulatory systems and represents an important factor ensuring cell viability. Redox-dependent regulation of cellular processes is a multi-level system including not only proteins and enzyme complexes, but also non-coding RNAs, among which an important role belongs to microRNAs. The review focuses on the involvement of miRNAs in the redox-dependent regulation of both ROS (reactive oxygen species)-generating enzymes and antioxidant enzymes with special emphasis on the effects of miRNAs on redox-dependent processes in tumor cells. The impact of ROS on the miRNA expression and the role of the ROS/miRNA feedback regulation in the cell redox state are discussed.
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