An estimation of pharmacokinetic parameters for each dosing at unequal doses and dosing intervals

The calculations of pharmacokinetic parameters for each dosing at unequal doses and dosing intervals were proposed. Systemic clearance of a drug following one-compartment open model can be determined by the product of the apparent first-order elimination rate constant and the apparent volume of distribution. The determination of maximum plasma concentration (Cmax) and the time required for the Cmax at each dosing were also presented here. These theoretical considerations are applicable to multicompartment open model.