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Combination of Microstereolithography and Electrospinning to Produce Membranes Equipped with Niches for Corneal Regeneration
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Innovative tailor made dextran based membranes with excellent non-inflammatory response: In vivo assessment.

A C Pinho1, A C Fonseca1, A R Caseiro2

  • 1CEMMPRE, Department of Chemical Engineering, Rua Sílvio Lima-Pólo II, 3030-790, Coimbra, Portugal.

Materials Science & Engineering. C, Materials for Biological Applications
|November 26, 2019
PubMed
Summary

New dextran-based membranes were developed for tissue engineering and regenerative medicine (TERM). These biocompatible and thermally stable materials show promise for implantable devices with minimal adverse tissue response.

Keywords:
DextranMembranesPhotopolymerizationRegenerative medicinepoly(ε-caprolactone)

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Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Tissue Engineering and Regenerative Medicine (TERM)

Background:

  • Developing advanced materials is crucial for regenerative medicine.
  • Dextran and poly(ε-caprolactone) (PCL) are FDA-approved polymers with potential for biomedical applications.
  • Functionalization and photocrosslinking offer a versatile strategy for creating novel biomaterials.

Purpose of the Study:

  • To prepare and characterize dextran-based membranes for TERM applications.
  • To investigate the physicochemical properties, degradation, and biocompatibility of these novel membranes.
  • To evaluate the potential of these membranes as implantable devices.

Main Methods:

  • Dextran and PCL were functionalized with methacrylate groups.
  • Photocrosslinking was employed to create membranes with varying polymer ratios.
  • Physicochemical properties (thermal stability, Tg, flexibility, swelling), in vitro hydrolytic degradation, cytotoxicity (hDPSCs), and in vivo biocompatibility (subcutaneous implantation in rats) were assessed.

Main Results:

  • Transparent membranes with tunable properties were successfully prepared.
  • All formulations exhibited excellent thermal stability (up to 300°C) and structural integrity for over 30 days in vitro.
  • Preliminary biological tests showed no cytotoxicity and promising in vivo biocompatibility, with some formulations classified as non-irritant.

Conclusions:

  • The developed dextran-based membranes possess favorable physicochemical and biological properties for TERM.
  • These materials demonstrate potential as engineered devices for biomedical applications.
  • The tunable nature and biocompatibility suggest suitability for supporting cell adhesion and viability in regenerative medicine strategies.