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Updated: Jan 3, 2026
Fabrication of a Biomimetic Nano-Matrix with Janus Base Nanotubes and Fibronectin for Stem Cell Adhesion
Published on: May 10, 2020
Hyaluronic acid/corn silk extract based injectable nanocomposite: A biomimetic antibacterial scaffold for bone tissue
Pooyan Makvandi1, Ghareib W Ali2, Francesca Della Sala3
1Institute for Polymers, Composites and Biomaterials, National Research Council, IPCB-CNR, Naples, Italy; Department of Chemical, Materials and Production Engineering, University of Naples Federico II, Naples, Italy.
Abstract:
Injectable hydrogels have revealed the great potential for use as scaffolds in cartilage and bone tissue engineering. Here, thermosensitive and injectable hydrogels containing β-tricalcium phosphate, hyaluronic acid, and corn silk extract-nanosilver (CSE-Ag NPs) were synthesized for their potential use in bone tissue regeneration applications. Spherical nanoparticles of silver were biosynthesized through microwave-assisted green approach using CSE in organic solvent-free medium. Rheological experiments demonstrated that the thermosensitive hydrogels have gelification temperature (Tgel) close to body temperature. The samples containing Ag NPs showed antibacterial activity toward gram-positive (Bacillus Subtilis, Staphylococcus Aureus) and gram-negative (Pseudomonas Aeruginosa, Escherichia Coli) bacteria along without cytotoxicity after 24 h. Mesenchymal stem cells seeded in the nanocomposite exhibited high bone differentiation which indicate that thay could be a good candidate as a potential scaffold for bone tissue regeneration.
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