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[DPEPhosbcpCu]PF6: A General and Broadly Applicable Copper-Based Photoredox Catalyst
Published on: May 21, 2019
Synergistic Pd/Cu Catalysis in Organic Synthesis
Yue Wu1,2, Xiaohong Huo1, Wanbin Zhang1,3
1Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs, School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai, 200240, P. R. China.
Synergistic palladium/copper (Pd/Cu) catalysis is a powerful tool for organic synthesis, enabling efficient cross-coupling and asymmetric reactions. This review highlights its recent advancements and underlying mechanisms in catalysis.
Area of Science:
- Organic Chemistry
- Catalysis
- Organometallic Chemistry
Background:
- Synergistic palladium/copper (Pd/Cu) catalysis has been employed in the Sonogashira reaction since 1975.
- This catalytic strategy has gained recent attention within the organic chemistry community.
- It is emerging as a proficient method for developing novel catalytic reactions.
Purpose of the Study:
- To provide an overview of synergistic Pd/Cu catalysis in organic synthesis.
- To highlight the development of this catalytic approach.
- To discuss the reaction mechanisms involved.
Main Methods:
- Review of existing literature on synergistic Pd/Cu catalysis.
- Analysis of applications in cross-coupling reactions.
- Examination of asymmetric synthesis methodologies.
Main Results:
- Synergistic Pd/Cu catalysis facilitates efficient cross-coupling reactions.
- This approach enables challenging asymmetric reactions, including stereodivergent synthesis.
- Recent discoveries showcase the versatility of combined chiral and achiral metal catalysts.
Conclusions:
- Synergistic Pd/Cu catalysis is a rapidly developing field in organic synthesis.
- Understanding the reaction mechanisms is crucial for further advancements.
- This strategy offers significant potential for creating complex molecules.
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