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Related Concept Videos

Teeth01:15

Teeth

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The formation of teeth, also known as odontogenesis, is a complex process that begins in utero, around the sixth week of embryonic development. There are three stages to this process: the bud stage, the cap stage, and the bell stage.
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Tooth Anatomy01:21

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The human tooth enables us to eat a variety of foods, speak clearly, and even aid in shaping our faces. Teeth are composed of various elements that work together. Here's a detailed look at the anatomy of a human tooth.
The Crown, Neck, and Root
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Determination01:51

Determination

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During embryogenesis, cells become progressively committed to different fates through a two-step process: specification followed by determination. Specification is demonstrated by removing a segment of an early embryo, “neutrally” culturing the tissue in vitro—for example, in a petri dish with simple medium—and then observing the derivatives. If the cultured region gives rise to cell types that it would normally generate in the embryo, this means that it is specified. In...
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Gastrulation01:56

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Gastrulation establishes the three primary tissues of an embryo: the ectoderm, mesoderm, and endoderm. This developmental process relies on a series of intricate cellular movements, which in humans transforms a flat, “bilaminar disc” composed of two cell sheets into a three-tiered structure. In the resulting embryo, the endoderm serves as the bottom layer, and stacked directly above it is the intermediate mesoderm, and then the uppermost ectoderm. Respectively, these tissue strata...
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Bone Formation by Intramembranous Ossification01:29

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Intramembranous ossification is one of the two processes involved in the development of bones within an embryo. The flat bones of the face, most of the cranial bones, and the clavicles are formed via this process. During intramembranous ossification, the bones develop directly from sheets of undifferentiated mesenchymal connective tissue.
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Changes in the Appendicular Skeleton with Age01:09

Changes in the Appendicular Skeleton with Age

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The upper and lower limb initially develops as a small bulge called a limb bud, which appears on the lateral side of the early embryo. The upper limb bud appears near the end of the fourth week of development, with the lower limb bud appearing shortly after.
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Assessing Species-specific Contributions To Craniofacial Development Using Quail-duck Chimeras
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Developmental mechanisms driving complex tooth shape in reptiles.

Marie Landova Sulcova1,2, Oldrich Zahradnicek3, Jana Dumkova4

  • 1Laboratory of Molecular Morphogenesis, Institute of Animal Physiology and Genetics, Czech Academy of Science, Brno, Czech Republic.

Developmental Dynamics : an Official Publication of the American Association of Anatomists
|November 26, 2019
PubMed
Summary
This summary is machine-generated.

Reptilian tooth development involves enamel knot-like signaling centers that orchestrate complex tooth shapes through cell signaling and rearrangement, similar to mammals. These structures guide enamel ridge formation during odontogenesis.

Keywords:
Na,K-ATPaseSHHchameleoncrocodileenamel ridgegeckomatriptasenuclei shapetooth shape

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Area of Science:

  • Developmental Biology
  • Evolutionary Biology
  • Comparative Anatomy

Background:

  • Mammalian tooth development relies on enamel knots (EKs) for dental epithelium shaping.
  • Reptilian tooth shape development mechanisms remain largely unknown.
  • This study investigates signaling organizers in reptilian odontogenesis and enamel ridge formation.

Purpose of the Study:

  • To determine if enamel knot-like structures exist in reptiles.
  • To understand the role of these structures in forming complex reptilian tooth shapes.
  • To elucidate the mechanisms of enamel ridge formation in reptiles.

Main Methods:

  • Comparative morphological analysis of reptilian tooth development.
  • Immunohistochemistry for key signaling molecules (SHH, FGF4, ST14, GLI2).
  • 3D nuclear shape analysis and ultrastructural examination of epithelial cells.

Main Results:

  • Reptilian odontogenesis features EK-like structures with apoptotic cells and no proliferation.
  • Mammalian EK-specific molecule expression (SHH, FGF4, ST14) and GLI2-negative cells observed in reptilian EK-like areas.
  • Cellular rearrangements, ultrastructural changes, and altered molecule expression (Na/K-ATPase, F-actin) correlate with enamel ridge formation.

Conclusions:

  • Reptilian tooth complexity arises from coordinated cell signaling, shape changes, and rearrangement.
  • Asymmetry in inner enamel epithelium development drives enamel deposition and ridge formation.
  • Signaling organizers similar to mammalian EKs play a role in reptilian tooth morphogenesis.