Evaluation of the Occlusive Arterial Disease and Diabetic Angiopathy Treatment Effects by Hyperbaric Oxygenation
1Department of Angiology, Clinic of Heart, Blood Vessel and Rheumatic Diseases, Clinical Center University of Sarajevo, Bosnia and Herzegovina.
Insights
Hyperbaric oxygen (HBO) therapy significantly improves healing for patients with arterial occlusive disease (AOD) and diabetic angiopathy (DA) lower-extremity wounds. This therapy reduces amputations when added to standard treatments.
Area of Science:
- Vascular Medicine
- Wound Healing
- Hyperbaric Medicine
Background:
- Arterial occlusive disease (AOD) and diabetic angiopathy (DA) are common causes of chronic lower-extremity wounds.
- These conditions often lead to severe complications, including limb loss.
- Hyperbaric oxygen (HBO) therapy is a recognized treatment for hypoxia.
Purpose of the Study:
- To compare hyperbaric oxygen (HBO) therapy combined with standard treatment against standard treatment alone for AOD and DA.
- To evaluate the efficacy of HBO therapy in improving ischemic symptomatology and wound healing.
- To demonstrate the specific benefits of HBO therapy as an adjunct treatment.
Main Methods:
- A prospective clinical study involving 80 patients with AOD and DA lower-extremity wounds.
- Patients were divided into two groups: AOD and DA.
- Sub-groups received either standard therapy alone or standard therapy plus HBO therapy.
Main Results:
- Therapy combining HBO with standard treatment showed significantly higher efficacy compared to standard treatment alone.
- Nine patients receiving HBO therapy experienced significant improvement.
- Only one patient in the non-HBO group showed significant improvement.
Conclusions:
- HBO therapy is an effective component in healing diabetic lower-extremity wounds in patients with AOD and DA.
- Adding HBO therapy to standard protocols reduced lower-limb amputations in the study cohort.
- These findings support the clinical use of HBO therapy for promoting diabetic wound healing.
Introduction:
One of the most severe complications of atherosclerosis is arterial occlusive disease (AOD) and with diabetic angiopathy (DA), is a common chronic problem in clinical practice worldwide. Hyperbaric oxygen (HBO) therapy is a therapeutic modality for solving all forms of hypoxia.
Aim:
To compare the treatment with HBO therapy in patients with AOD and DA ischemic symptomatology with standard treatment i.e. vasodilators, antibiotics, antiplatelets and statins, and to demonstrate the benefit of the therapeutic modality itself.
Methods:
We conducted a clinical prospective study and included a total of 80 patients, divided into two groups: 40 patients with the arterial occlusive disease and lower-extremity wounds, with sub-group (n=20) treated with HBO therapy on the top of the standard therapy and 40 patients with diabetic angiopathy and diabetic lower-extremity wounds, with sub-group (n=20) treated with HBO therapy on top of the standard therapy.
Results:
The efficacy of therapy in patients treated with HBO therapy on the top of standard therapy was significantly higher than in the group of HBO non-treated patients. There was a significant improvement in 9 patients treated with HBO therapy, while in HBO non-treated patients the significant improvement effect was observed only in one patient.
Conclusion:
HBO therapy is an effective therapeutic component in the healing of diabetic lower-extremity wounds in the patients with AOD and DA. In our patients HBO therapy on the top of standard therapeutic protocol has an effect of reducing the number of lower-limb amputations in patients with AOD and DA. These results support clinical use of HBO therapy for diabetic lower-extremity wound healing.
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