Smart H₂S-Triggered/Therapeutic System (SHTS)-Based Nanomedicine

Area of Science:

• Biomedical Engineering
• Nanotechnology
• Chemical Sensing

Background:

• Hydrogen sulfide (H2S) plays crucial roles in biological and physical processes.
• Elevated H2S levels are linked to diseases, notably cancer, underscoring the need for specific detection.
• Nanotechnology significantly improves chemical sensing probe performance through enhanced efficiency and sensitivity.

Purpose of the Study:

• To review and discuss the latest smart H2S-triggered/therapeutic system (SHTS) nanoplatforms.
• To cover therapeutic strategies involving endogenous H2S as a trigger or exogenous H2S delivery.
• To facilitate innovation in H2S-based nanomedicine by providing a comprehensive overview.

Main Methods:

• Literature review and synthesis of recent research on SHTS nanoplatforms.
• Detailed discussion of SHTS-based nanomaterials and their applications.
• Analysis of therapeutic strategies utilizing H2S modulation.

Main Results:

• SHTS nanoplatforms are emerging for advanced H2S-activated sensing, imaging, and therapy.
• Both endogenous H2S triggering and exogenous H2S delivery strategies are being explored.
• Current research focuses on optimizing nanomaterial design for specific applications.

Conclusions:

• A thorough understanding of SHTS strategies is vital for advancing H2S-related diagnostics and therapeutics.
• Key challenges include nanomaterial design, surface modification, and therapeutic strategy selection.
• Future development requires addressing morphology, application appropriateness, and material selection for SHTS.