Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Olfactory Receptors: Location and Structure01:03

Olfactory Receptors: Location and Structure

11.0K
The process of olfaction, also known as the sense of smell, is a sophisticated chemical response system. The specialized sensory neurons that facilitate this process, known as olfactory receptor neurons, are situated in an upper segment of the nasal cavity, known as the olfactory epithelium. Olfactory sensory neurons are bipolar, with their dendrites extending from the epithelium's apex into the mucus that lines the nasal cavity. Airborne molecules, when inhaled, traverse the olfactory...
11.0K
Physiology of Smell and Olfactory Pathway01:20

Physiology of Smell and Olfactory Pathway

12.0K
Humans detect odors with the help of specialized cells located in the upper part of the nasal cavity, called olfactory receptor neurons (ORNs). ORNs possess hair-like structures called cilia, which are receptive to sensations from the inhaled air. When an odorant molecule binds to a specific receptor on the cell of the cilia, it leads to a series of events that ultimately cause the ORN to send electrical signals to the olfactory bulb in the brain through the olfactory nerves.
The olfactory...
12.0K
Olfaction01:25

Olfaction

47.9K
The sense of smell is achieved through the activities of the olfactory system. It starts when an airborne odorant enters the nasal cavity and reaches olfactory epithelium (OE). The OE is protected by a thin layer of mucus, which also serves the purpose of dissolving more complex compounds into simpler chemical odorants. The size of the OE and the density of sensory neurons varies among species; in humans, the OE is only about 9-10 cm2.
The olfactory receptors are embedded in the cilia of the...
47.9K
Nose and Nasal Cavity01:24

Nose and Nasal Cavity

9.7K
The nose is composed of an observable exterior segment (external nose) and an internal segment within the skull known as the nasal cavity (internal nose). The external nose, visible on the face, consists of a framework of bone and hyaline cartilage enveloped in skin and muscle and lined with a mucous membrane. This structure is supported by the frontal bone, nasal bones, and maxillary bone and is supplemented by a cartilaginous framework comprising the septal nasal cartilage, lateral nasal...
9.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Synthesis, In silico Studies, and Biological Evaluation of Benzotriazole-Fused Thiazole-containing Schiff Bases as Potential Therapeutic Agents for Microbial Infections in Respiratory Disorders.

Recent advances in anti-infective drug discovery·2026
Same author

Assessing the impact of carbamate insecticide aminocarb on human plasma protein through biophysical and computational methods.

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy·2026
Same author

Genetic polymorphisms of cytokine genes and their role in the susceptibility and severity of allergic fungal rhinosinusitis.

Archives of microbiology·2025
Same author

Pediatric Atypical Teratoid Rhabdoid Tumor of Central Nervous System: A Case Series with Review of Literature.

Indian journal of surgical oncology·2025
Same author

Three Novel Species of Earthworms of Genus Metaphire Sims and Easton, 1972 from Manipur, India.

Zootaxa·2025
Same author

Discovery of a novel species of the genus Perionyx Perrier, 1872 (Clitellata: Megascolecidae) from Manipur, North-Eastern Region, India.

Zootaxa·2025
Same journal

Correction: Tracheostomy Management in Oral and Oropharyngeal Carcinoma Patients: A Retrospective Study from a Multidisciplinary Protocol Approach.

Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India·2026
Same journal

Correction: Screening of Oropharyngeal Dysphagia, Laryngopharyngeal Reflux and Job Burnout in Adult Patients with Obstructive Sleep Apnea Syndrome.

Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India·2026
Same journal

Correction: Comparison of the Use of Autologous Platelet Rich Plasma with Conventional Method in Myringoplasty.

Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India·2026
Same journal

Correction to: Digital Eye Strain and Dry Nose: an Observational Study on Screen OverUse and Emerging Otorhinolaryngological Symptoms in Young Adults.

Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India·2026
Same journal

Correction: Retrospective Observational Study To Analyse Indications of Cochleostomy and Changing Trends in Use of Cochleostomy for Cochlear Implant Electrode Insertion.

Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India·2026
Same journal

Correction: Sinonasal Clear Cell Carcinoma Masquerading as Recurrent Inverted Papilloma.

Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India·2026
See all related articles

Related Experiment Video

Updated: Jan 3, 2026

Author Spotlight: Advancing Allergic Rhinitis Research with Multicolor Immunofluorescence
06:08

Author Spotlight: Advancing Allergic Rhinitis Research with Multicolor Immunofluorescence

Published on: September 22, 2023

2.4K

Olfaction and Its Correlates in Allergic Rhinitis: A Case Control Study.

Neelima Gupta1, Anshika Harit1, H C Taneja1

  • 11Department of Otorhinolaryngology, University College of Medical Sciences and GTB Hospital, University of Delhi, Delhi, 110095 India.

Indian Journal of Otolaryngology and Head and Neck Surgery : Official Publication of the Association of Otolaryngologists of India
|November 26, 2019
PubMed
Summary
This summary is machine-generated.

Allergic rhinitis often causes reduced sense of smell (olfactory dysfunction). While nasal airflow and inflammation markers like IgE and IL-5 are altered, their exact role in smell impairment remains unclear.

Keywords:
Allergic rhinitisHyposmiaInflammatory markersOlfaction

More Related Videos

Real-time In Vitro Monitoring of Odorant Receptor Activation by an Odorant in the Vapor Phase
09:53

Real-time In Vitro Monitoring of Odorant Receptor Activation by an Odorant in the Vapor Phase

Published on: April 23, 2019

7.4K
Symptom Assessment of Patients with Allergic Rhinitis Using an Allergen Exposure Chamber
08:47

Symptom Assessment of Patients with Allergic Rhinitis Using an Allergen Exposure Chamber

Published on: March 3, 2023

2.9K

Related Experiment Videos

Last Updated: Jan 3, 2026

Author Spotlight: Advancing Allergic Rhinitis Research with Multicolor Immunofluorescence
06:08

Author Spotlight: Advancing Allergic Rhinitis Research with Multicolor Immunofluorescence

Published on: September 22, 2023

2.4K
Real-time In Vitro Monitoring of Odorant Receptor Activation by an Odorant in the Vapor Phase
09:53

Real-time In Vitro Monitoring of Odorant Receptor Activation by an Odorant in the Vapor Phase

Published on: April 23, 2019

7.4K
Symptom Assessment of Patients with Allergic Rhinitis Using an Allergen Exposure Chamber
08:47

Symptom Assessment of Patients with Allergic Rhinitis Using an Allergen Exposure Chamber

Published on: March 3, 2023

2.9K

Area of Science:

  • Rhinology
  • Immunology
  • Neuroscience

Background:

  • Olfactory dysfunction is common in rhinological diseases, potentially due to nasal obstruction or inflammation.
  • The precise mechanisms causing smell impairment in allergic rhinitis require further elucidation.

Purpose of the Study:

  • To assess olfactory function in allergic rhinitis patients.
  • To correlate olfactory scores with nasal airflow, peripheral eosinophilia, and local IgE and IL-5 levels.
  • To investigate the pathogenesis of olfactory impairment in allergic rhinitis.

Main Methods:

  • Olfactory scores were evaluated in 40 allergic rhinitis patients and 40 healthy controls.
  • Nasal airflow, peripheral eosinophilia, and IgE and IL-5 levels in nasal secretions were measured.
  • Statistical correlations were performed between olfactory scores and measured variables.

Main Results:

  • Allergic rhinitis patients exhibited significantly lower olfactory scores compared to controls.
  • While a weak correlation was observed between olfactory score and nasal airflow, it was not statistically significant.
  • Peripheral eosinophilia and local IgE and IL-5 levels were elevated in patients but did not correlate significantly with olfactory scores.

Conclusions:

  • Allergic rhinitis is associated with decreased olfactory function.
  • Both impaired nasal airflow and local inflammation (IgE, IL-5) may contribute to smell loss, but their specific roles are not definitively established.
  • Further research is needed to clarify the primary drivers of hyposmia in allergic rhinitis.