Acute Toxin-mediated Rhabdomyolysis During Treatment With Trimethoprim-sulfamethoxazole
Michael Sperandeo1,2,3, Dorjan Pantic1,2,3, Jessica Army1,2,3
1Northwell Health at North Shore University Hospital, Department of Emergency Medicine, Manhasset, New York.
Abstract:
Rhabdomyolysis is a condition in which skeletal muscle breakdown causes the release of intracellular components into the bloodstream - defined as elevations in serum creatine kinase levels. The etiology of rhabdomyolysis is varied and may be the result of toxin-mediated mechanisms or metabolic derangements, or they may develop secondary to other conditions such as seizures, trauma and prolonged immobilization. In this case, we present a patient with suspected acute toxin-mediated rhabdomyolysis in the setting of trimethoprim-sulfamethoxazole (TMP-SMX) therapy for urinary tract infection. To our knowledge, this marks the fifth case report of an otherwise healthy patient diagnosed with rhabdomyolysis thought to be secondary to TMP-SMX.
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