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Related Concept Videos

Antiepileptic Drugs: Potassium Channel Activators01:20

Antiepileptic Drugs: Potassium Channel Activators

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Ezocgabine or retigabine, an antiepileptic drug of remarkable efficacy, has revolutionized the management of seizures. It is a potassium channel activator, explicitly targeting the family of Q subtype potassium channels. It enhances the transmembrane potassium currents, regulating neuronal excitability. This action stabilizes the resting membrane potential, a pivotal factor in mitigating the hyperexcitability that characterizes epilepsy.
Ezogabine has gained approval as an adjunctive treatment...
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Epilepsy and Seizures: Overview01:24

Epilepsy and Seizures: Overview

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Epilepsy is a chronic neurological disease marked by recurrent, unpredictable seizures. These seizures are caused by abnormal electrical discharges in the brain, leading to behavior, sensation, or consciousness alterations. They can also cause transient impairment of awareness, interfering with daily activities.
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...
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Seizures: Classification01:13

Seizures: Classification

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Epilepsy is primarily characterized by unpredictable seizures, either provoked by an identifiable factor, such as injury or illness, or unprovoked, occurring spontaneously without apparent cause.
Seizures are typically classified into two main categories: focal and generalized seizures.
Focal Seizures
Focal seizures originate from specific regions of the brain. These seizures are further sub-classified into two types:
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Antiepileptic Drugs: GABAergic Pathway Potentiators01:18

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γ-aminobutyric acid or GABA, plays a pivotal role as an inhibitory neurotransmitter in the brain. GABA pathway potentiators, also known as GABAergic drugs, are a class of pharmaceutical agents designed to enhance the functioning of the GABAergic system. These medications primarily treat epilepsy, a neurological disorder characterized by recurrent seizures.
The key GABA pathway potentiators used in epilepsy management are as follows.
Benzodiazepines are a well-known class of drugs used for...
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Parenteral Anesthetics: Overview01:24

Parenteral Anesthetics: Overview

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Intravenous anesthetics are drugs administered parenterally to induce anesthesia or sedation. Propofol is a widely used agent formulated as a 1% emulsion in soybean oil, glycerol, and egg phosphatide. It induces rapid anesthesia primarily due to its rapid distribution from the bloodstream to target tissues and is metabolized in the liver. However, it can cause significant pain on injection and hypertriglyceridemia. Fospropofol, a water-based prodrug of propofol, lacks these adverse effects.
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Antiepileptic Drugs: Glutamate Antagonists01:14

Antiepileptic Drugs: Glutamate Antagonists

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Glutamate is a fundamental neurotransmitter in the central nervous system, playing a vital role in neuronal communication and various cognitive processes. Glutamate stands as the principal excitatory neurotransmitter in the brain. Its presence is crucial for the communication between neurons, underpinning essential processes such as synaptic transmission, neuronal excitability, and plasticity. These functions are vital for higher-order cognitive processes, including learning and memory. The...
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Related Experiment Video

Updated: Jan 3, 2026

Pentylenetetrazole-Induced Kindling Mouse Model
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Ketamine Implicated in New Onset Seizure.

Christopher W Meaden1, Stacey Barnes1

  • 1St. Joseph's University Medical Center, Department of Emergency Medicine, Paterson, New Jersey.

Clinical Practice and Cases in Emergency Medicine
|November 26, 2019
PubMed
Summary

Ketamine, used for procedural sedation, may rarely induce seizures, even in patients without a history of epilepsy. This case highlights a potential adverse event for emergency providers to consider.

Area of Science:

  • Emergency Medicine
  • Neuroscience
  • Pharmacology

Background:

  • Ketamine is a widely used anesthetic in emergency departments for procedural sedation and pain management.
  • Its benefits include rapid onset and minimal respiratory depression.
  • Known side effects encompass emergence reactions, hallucinations, hypertension, dizziness, nausea, and vomiting.

Observation:

  • A case study involving a patient undergoing procedural sedation with ketamine as a single agent.
  • The patient had no prior history of seizures.

Findings:

  • The patient developed a seizure following ketamine administration.
  • This suggests ketamine may potentially induce seizures, an effect not previously documented in patients without a seizure history.

More Related Videos

Behavioral Characterization of Pentylenetetrazole-induced Seizures: Moving Beyond the Racine Scale
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Non-restraining EEG Radiotelemetry: Epidural and Deep Intracerebral Stereotaxic EEG Electrode Placement
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Related Experiment Videos

Last Updated: Jan 3, 2026

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Behavioral Characterization of Pentylenetetrazole-induced Seizures: Moving Beyond the Racine Scale
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Non-restraining EEG Radiotelemetry: Epidural and Deep Intracerebral Stereotaxic EEG Electrode Placement
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Implications:

  • This case presents a novel adverse effect of ketamine, potentially inducing seizures.
  • Emergency providers should be aware of this rare possibility, especially when considering ketamine for procedural sedation.
  • Further research is warranted to understand this phenomenon and its implications for patient safety.