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Published on: September 11, 2018
Trikoramide A, a Prenylated Cyanobactin from the Marine Cyanobacterium Symploca hydnoides
Ma Yadanar Phyo1,2, Chi Ying Gary Ding1, Hui Chin Goh3
1Natural Sciences and Science Education, National Institute of Education , Nanyang Technological University , 1 Nanyang Walk , Singapore 637616 , Singapore.
Abstract:
A new cyclic decapeptide, trikoramide A (1), has been isolated from samples of the marine cyanobacterium Symploca hydnoides, collected from Bintan Island, Indonesia. Trikoramide A (1) is a C-prenylated cyclotryptophan-containing cyanobactin. Its planar structure was deduced by 1D and 2D NMR spectroscopy as well as HR-MS/MS data. In addition, its absolute configuration was determined by Marfey's method and 2D NOESY NMR spectroscopic analysis. Compound 1 possessed cytotoxicity against the MOLT-4 and AML2 cancer cell lines with IC50 values of 4.8 and 8.2 μM, respectively.
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