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The peripheral T and B lymphocytes in uremic patients
Archivum Immunologiae Et Therapiae Experimentalis
|January 1, 1979
Summary
Patients with terminal renal failure show reduced B-cells, especially those on hemodialysis. Immune disturbance severity in chronic renal failure correlates with disease duration, not dialysis treatment.
Area of Science:
- Immunology
- Nephrology
Background:
- Chronic renal failure (CRF) significantly impacts the immune system.
- Understanding immune cell alterations in CRF is crucial for patient management.
Purpose of the Study:
- To determine peripheral T and B lymphocyte levels in patients with end-stage renal disease (ESRD).
- To compare immune cell profiles between diet-treated and hemodialysis-treated ESRD patients.
- To investigate the relationship between immune status, dialysis, and renal insufficiency duration.
Main Methods:
- Utilized the rosette technique to quantify peripheral T and B lymphocytes.
- Compared lymphocyte counts in 24 diet-treated ESRD patients and 17 hemodialysis-treated ESRD patients against a control group.
Main Results:
- Both patient groups exhibited a decreased percentage of B-cells compared to controls.
- Hemodialysis patients showed a more pronounced decrease in B-cells than undialyzed patients, though not statistically significant.
- The extent of immune disturbance was linked to the duration of renal insufficiency, independent of dialysis.
Conclusions:
- Terminal renal failure is associated with a reduction in B-lymphocytes.
- Immune system impairment in CRF is primarily influenced by the duration of the condition rather than the modality of treatment (diet vs. dialysis).