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Endothelial dysfunction predicted increased left atrial volume index in newly diagnosed nondiabetic hypertensive

Mustafa Çetin1, Turan Erdoğan1, Tuncay Kiriş2

  • 1Department of Cardiology, Recep Tayyip Erdogan Research and Training Hospital, Rize.

Blood Pressure Monitoring
|November 26, 2019
PubMed

Insights

Endothelial dysfunction, indicated by reduced flow-mediated dilation (FMD%), predicts left atrial volume increase in new hypertension patients. This highlights FMD% as a key predictor for cardiovascular risk in hypertension.

Area of Science:

  • Cardiology
  • Vascular Biology
  • Hypertension Research

Background:

  • Arterial hypertension is a major risk factor for cardiovascular morbidity and mortality.
  • Left atrial volume increase is linked to adverse cardiovascular outcomes, including mortality and atherosclerotic heart disease.
  • Predicting left atrial volume changes is crucial for managing hypertension-related cardiovascular risk.

Purpose of the Study:

  • To investigate the predictive value of endothelial dysfunction for left atrial volume increase.
  • To assess the relationship between brachial artery flow-mediated dilation (FMD%) and left atrial volume in newly diagnosed hypertension.

Main Methods:

  • Study included 96 newly diagnosed hypertensive patients.
  • Measurements included left atrium volume, left ventricular ejection fraction, pulse wave velocity, and brachial artery flow-mediated dilation (FMD%).

Main Results:

  • Patients with higher left atrial volume index showed significantly increased left ventricle mass index, septal and posterior wall thickness, and end-diastolic diameter.
  • Flow-mediated dilation (FMD%) was significantly lower in patients with higher left atrial volume index (9.7 ± 3.5% vs. 13.31 ± 6.01%).
  • Higher left atrial volume index was associated with lower lateral wall E wave velocity, longer isovolumetric relaxation time, and higher E/E' ratio.

Conclusions:

  • Isovolumetric relaxation time, flow-mediated dilation (FMD%), and the E/E' ratio independently predict left atrial volume index increase in newly diagnosed hypertension.
  • Endothelial dysfunction, assessed by FMD%, is a valuable predictor of left atrial remodeling in early hypertension.
Abstract

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