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Updated: Jan 3, 2026

Evaluation of Colorectal Cancer Risk and Prevalence by Stool DNA Integrity Detection

Evaluation of Colorectal Cancer Risk and Prevalence by Stool DNA Integrity Detection

Published on: June 8, 2020

Multitarget Stool DNA Test Performance in an Average-Risk Colorectal Cancer Screening Population.

L J W Bosch¹, V Melotte², S Mongera³

¹Department of Pathology, Netherlands Cancer Institute, Amsterdam, the Netherlands.

The American Journal of Gastroenterology

|November 26, 2019

Summary

This summary is machine-generated.

The multitarget stool DNA (MT-sDNA) test shows higher sensitivity for detecting advanced precancerous lesions than the fecal immunochemical test (FIT) in average-risk screening. However, neither test significantly improved detection of high-risk advanced adenomas.

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Evaluation of Colorectal Cancer Risk and Prevalence by Stool DNA Integrity Detection

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Integration of Wet and Dry Bench Processes Optimizes Targeted Next-generation Sequencing of Low-quality and Low-quantity Tumor Biopsies

Integration of Wet and Dry Bench Processes Optimizes Targeted Next-generation Sequencing of Low-quality and Low-quantity Tumor Biopsies

Published on: April 11, 2016

Area of Science:

Gastroenterology
Oncology
Molecular Diagnostics

Background:

Colorectal cancer (CRC) screening is crucial for early detection and prevention.
Multitarget stool DNA (MT-sDNA) tests offer a non-invasive approach to CRC screening.
Fecal immunochemical test (FIT) is a common, less sensitive screening method.

Purpose of the Study:

To evaluate the performance of an MT-sDNA test compared to FIT in an average-risk CRC screening population.
To assess the sensitivity and specificity of MT-sDNA for detecting various colorectal lesions, including advanced adenomas.
To compare the detection rates of high-risk advanced adenomas between MT-sDNA and FIT.

Main Methods:

Prospective collection of 1,047 whole stool samples for MT-sDNA testing (KRAS mutations, NDRG4/BMP3 methylation, hemoglobin).
Comparison of MT-sDNA results with FIT (various hemoglobin thresholds) for detecting CRC, advanced precancerous lesions, and non-advanced adenomas.
Definition of high-risk advanced adenomas using DNA copy number events from low-pass whole genome sequencing.

Main Results:

MT-sDNA demonstrated significantly higher sensitivity (46%) than FIT (27%) for advanced precancerous lesions (P < 0.001).
Specificities were comparable: MT-sDNA (89%) and FIT (93%) for non-advanced/negative findings.
MT-sDNA positivity correlated with multiple and larger lesions, and those with tubulovillous architecture.

Conclusions:

MT-sDNA offers improved sensitivity for detecting advanced precancerous lesions in average-risk screening compared to FIT alone.
Neither MT-sDNA nor FIT significantly enhanced the detection of high-risk advanced adenomas.
MT-sDNA shows promise as a more sensitive non-invasive screening tool for colorectal neoplasia.