Successful Treatment of Chronic Lower Extremity Ulcers with Allogeneic Platelet-Rich Plasma and Artificial Dermis: A Case Report
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Effects of Allogeneic Platelet-Rich Plasma PRP on the Healing Process of Sectioned Achilles Tendons of Rats: A Methodological Description
Published on: March 19, 2018
Qiannan Zhao1, Yuanyuan Ma, Yuquan Lu
1At the Huaihe Hospital of Henan University, Kaifeng, China, Qiannan Zhao, MA, is a graduate student, Department of Reconstructive and Plastic Surgery; Yuanyuan Ma, MD, is a plastic surgeon, Department of Reconstructive and Plastic Surgery; Yuquan Lu, PhD, is a professor, International Joint Research Laboratory for Cell Medical Engineering; Yuan Chai, MD, is a plastic surgeon, Department of Reconstructive and Plastic Surgery; and Yuemin Zhou, PhD, MD, is a professor, Department of Reconstructive and Plastic Surgery. Acknowledgments: This work was supported by the Medical Science and Technology Research Project of Henan Province (1721102410005). The authors have disclosed no financial relationships related to this article. Submitted April 12, 2019; accepted in revised form July 9, 2019.
Abstract:
Hydroxyurea is an oral medication associated with painful, nonhealing ulcers, for which there is no effective treatment but permanent discontinuation of hydroxyurea. The authors present a case of leg ulcers that likely occurred as a result of hydroxyurea use in a patient with essential thrombocythemia. Topical treatment with allogeneic platelet-rich plasma and artificial dermis completely healed the leg ulcers without hydroxyurea cessation.

