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[Comparative clinico-morphological research on measles and mumps infections in an experiment on guinea pigs]
Abstract:
The pathological process typical of measles and mumps infections was reproduced clinically and morphologically in 250 experimental guinea pigs infected into the anterior eye chamber with different strains of measles and mumps viruses. The intraocular inoculation of measles virus induced in guinea pigs the signs of iridocyclitis and follicular conjunctivitis, whereas inoculation of mumps virus induced dacryoadenitis as well as iridocyclitis and follicular conjunctivitis. The severity of the reproduced process and its dynamics correlated with the pathogenicity of measles and mumps virus strains used in the experiment. The specificity of pathological changes observed in the eye structures was verified virologically by the isolation of virus from the eye membranes and the presence of virus-neutralizing antibodies in the blood sera of the animals.
Insights
Measles and mumps viruses cause eye inflammation in guinea pigs, including iridocyclitis and conjunctivitis. Virus strain pathogenicity influenced disease severity, confirmed by viral isolation and antibody detection.
Area of Science:
- Ophthalmology
- Virology
- Pathology
Background:
- Measles and mumps are viral infections that can affect various organs.
- Ocular manifestations of these viral infections are not fully understood.
- Animal models are crucial for studying viral pathogenesis.
Purpose of the Study:
- To reproduce the pathological processes of measles and mumps in the eyes of guinea pigs.
- To investigate the specific ocular tissues affected by measles and mumps viruses.
- To correlate disease severity with viral strain pathogenicity.
Main Methods:
- Intraocular inoculation of measles and mumps viruses into the anterior eye chamber of 250 guinea pigs.
- Clinical and morphological assessment of ocular tissues.
- Virological confirmation including virus isolation and antibody detection.
Main Results:
- Measles virus induced iridocyclitis and follicular conjunctivitis.
- Mumps virus induced dacryoadenitis, iridocyclitis, and follicular conjunctivitis.
- Disease severity and progression correlated with the pathogenicity of the viral strains.
Conclusions:
- Measles and mumps viruses can induce specific pathological changes in the guinea pig eye.
- The study confirms the ocular tropism of these viruses and the role of strain pathogenicity.
- Virological methods validated the experimental findings.