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Reply: Botulinum Toxin versus Placebo: A Meta-Analysis of Prophylactic Treatment for Migraine

Eva Bruloy1, Raphael Sinna1, Jean-Louis Grolleau M D2

  • 1Department of Plastic Reconstructive and Aesthetic Surgery, University Hospital of Picardie, Amiens Picardie University Hospital, Amiens, France.

Plastic and Reconstructive Surgery
|November 26, 2019
PubMed
Abstract

No abstract available in PubMed .

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Directly acting muscle relaxants like dantrolene and botulinum toxin (BoNT) have distinct mechanisms and applications. Dantrolene, a hydantoin derivative, acts on the ryanodine receptor (RYR1) in skeletal muscle cells. RYR1 are calcium channels present at the sarcoplasmic reticulum membrane. In response to excitation, they release calcium ions from the sarcoplasmic reticulum to the cytosol. Calcium promotes actin-myosin-mediated contraction of muscles.
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