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Ibuprofen overdose--a prospective study.

A H Hall, S C Smolinske, K W Kulig

    The Western Journal of Medicine
    |June 1, 1988
    PubMed
    Summary
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    Ibuprofen overdose can cause serious toxicity, including organ failure and central nervous system depression. Most toxic reactions from ibuprofen ingestion occur within four hours.

    Area of Science:

    • Toxicology
    • Pharmacology
    • Clinical Medicine

    Background:

    • Ibuprofen is a common nonsteroidal anti-inflammatory drug (NSAID).
    • Overdose cases are reported to poison control centers.
    • Assessing ibuprofen overdose toxicity is crucial for patient management.

    Purpose of the Study:

    • To analyze the clinical outcomes of ibuprofen overdose.
    • To identify risk factors and symptoms associated with ibuprofen toxicity.
    • To determine the incidence of toxic reactions in reported cases.

    Main Methods:

    • Retrospective review of consecutively reported ibuprofen overdose cases.
    • Exclusion of cases with incomplete follow-up or co-ingestions.
    • Analysis of patient demographics, dosage, symptoms, and outcomes.

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    Main Results:

    • A toxic reaction occurred in 16% of eligible patients (7/45).
    • Symptoms included nausea, vomiting, CNS depression, coma, and renal failure.
    • One adult fatality was reported; pediatric patients showed a 13% reaction rate.
    • No toxicity was observed in patients ingesting <104 mg/kg; reactions occurred within 4 hours.

    Conclusions:

    • While often benign, ibuprofen overdose can lead to severe toxicity.
    • Prompt recognition and management are essential for adverse outcomes.
    • Dosage and time to ingestion are critical factors in ibuprofen toxicity.