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Related Concept Videos

Salivary Glands and Saliva01:23

Salivary Glands and Saliva

2.2K
The salivary glands, of which there are three pairs known as the parotid, submandibular, and sublingual glands, play a crucial role in maintaining oral health and initiating the digestive process. Positioned near the ears, beneath the masseter muscle, the parotid glands secrete saliva into the oral cavity through the parotid duct of Stensen. Meanwhile, the submandibular glands, located on the floor of the mouth, secrete saliva through channels named submandibular ducts. The sublingual glands,...
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Related Experiment Video

Updated: Jan 3, 2026

Retroductal Submandibular Gland Instillation and Localized Fractionated Irradiation in a Rat Model of Salivary Hypofunction
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Regional Differences following Partial Salivary Gland Resection.

K J O'Keefe1,2, K A DeSantis1,3, A L Altrieth1,2

  • 1Molecular, Cellular, Developmental, and Neural Biology Graduate Program, State University of New York, University at Albany, Albany, NY, USA.

Journal of Dental Research
|November 26, 2019
PubMed
Summary

Researchers studied salivary gland repair after partial resection. They found a normal healing response alongside an abnormal fibrotic response in specific regions, offering insights into mammalian regeneration.

Keywords:
extracellular matrixfibrosismacrophagesregenerationsubmandibular glandwound repair

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Area of Science:

  • Regenerative Medicine
  • Tissue Repair and Regeneration
  • Mammalian Organ Physiology

Background:

  • Partial organ resection is a clinical strategy and research model for studying tissue repair.
  • Salivary glands (SGs) possess regenerative potential, but mechanisms underlying repair and potential failure are not fully understood.
  • Investigating injury responses in SGs can reveal insights applicable to broader regenerative medicine.

Purpose of the Study:

  • To establish a murine submandibular salivary gland (SMG) partial resection model for studying repair mechanisms.
  • To analyze molecular and cellular changes following partial sialoadenectomy over 56 days.
  • To differentiate between normal wound healing and aberrant fibrotic responses within the same organ.

Main Methods:

  • Murine submandibular salivary gland (SMG) partial resection (sialoadenectomy).
  • Whole-gland measurements, microarray analysis for transcriptome changes, and quantitative immunohistochemistry (IHC) for protein expression (e.g., Ki67, M2 macrophages).
  • Longitudinal analysis over 56 days post-injury.

Main Results:

  • Partial SMG resection induced dynamic transcriptome changes within 3 days, resolving by day 14, with signatures for cell cycle, inflammation, and extracellular matrix (ECM) remodeling.
  • A transient, gland-wide proliferative response (Ki67+) in epithelial and stromal cells occurred from day 3 to day 14.
  • A distinct region exhibited a sustained fibrotic response with increased ECM deposition, persistent stromal cell proliferation, and M2 macrophage presence through day 56.

Conclusions:

  • The partial SMG resection model effectively demonstrates both normal healing and aberrant fibrotic responses within the same tissue.
  • Understanding the regional differences in wound healing is crucial for developing effective regenerative therapies.
  • This model can uncover mechanisms that impede mammalian wound healing and regeneration.