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Induction and Analysis of Epithelial to Mesenchymal Transition
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Reversal of Epithelial-Mesenchymal Transition by Natural Anti-Inflammatory and Pro-Resolving Lipids

Chang Hoon Lee1

  • 1College of Pharmacy, Dongguk University, Seoul 100-715, Korea.

Cancers
|November 27, 2019
PubMed

Insights

Epithelial mesenchymal transition (EMT) drives cancer progression. This study reviews how natural anti-inflammatory compounds and pro-resolving lipids can suppress EMT, offering potential new anticancer drug development pathways.

Area of Science:

  • Oncology
  • Molecular Biology
  • Pharmacology

Background:

  • Epithelial mesenchymal transition (EMT) is a critical cellular mechanism implicated in malignant cancer progression and metastasis.
  • Targeting EMT represents a promising strategy for developing novel anticancer therapeutics.

Purpose of the Study:

  • To provide an updated overview of recent research on EMT.
  • To explore the potential of natural anti-inflammatory compounds and pro-resolving lipids in suppressing EMT.

Main Methods:

  • Literature review of recent scientific publications on EMT.
  • Analysis of studies investigating the effects of natural compounds and lipids on EMT pathways.

Main Results:

  • EMT is a fundamental process in cancer advancement.
  • Natural anti-inflammatory agents and pro-resolving lipids demonstrate potential in inhibiting EMT.

Conclusions:

  • Suppression of EMT through natural compounds and lipids offers a viable strategy for anticancer drug discovery.
  • Further research into these natural agents could accelerate the development of effective cancer treatments.
Keywords:
epithelial mesenchymal transitioninflammationmalignant cancernatural anti-inflammatory compoundspro-resolving lipids

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