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Induction and Analysis of Epithelial to Mesenchymal Transition
10:37

Induction and Analysis of Epithelial to Mesenchymal Transition

Published on: August 27, 2013

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A "NOTCH" Deeper into the Epithelial-To-Mesenchymal Transition (EMT) Program in Breast Cancer

Rohan Kar1, Niraj Kumar Jha2, Saurabh Kumar Jha2

  • 1Indian Institute of Management Ahmedabad (IIMA), Gujarat 380015, India.

Genes
|November 27, 2019
PubMed

Insights

Notch signaling, a primitive pathway, is implicated in cancer development. This review explores how Notch signaling drives breast cancer progression by regulating epithelial-mesenchymal transition (EMT).

Area of Science:

  • Molecular Biology
  • Developmental Biology
  • Oncology

Background:

  • Notch signaling is crucial for multicellular organism development.
  • Aberrations in Notch signaling are linked to cancer, with Notch recognized as an oncogene for over two decades.
  • Activated Notch signaling and its target genes are observed in human breast cancer, correlating with poor prognosis.

Purpose of the Study:

  • To review recent advancements in understanding Notch-mediated regulation of epithelial-mesenchymal transition (EMT) in breast tumorigenesis.
  • To elucidate the molecular mechanisms by which Notch signaling influences breast cancer development.

Main Methods:

  • Literature review of recent progress in breast cancer research.
  • Analysis of molecular mechanisms linking Notch signaling to EMT.
  • Exploration of Notch's role in breast carcinogenesis and metastasis.

Main Results:

  • Notch signaling plays a key role in breast carcinogenesis.
  • Notch signaling regulates epithelial-mesenchymal transition (EMT), a process hijacked by cancer cells for metastasis.
  • Over-expression of Notch ligands and receptors is associated with poor breast cancer prognosis.

Conclusions:

  • Notch signaling is a significant factor in breast cancer development and progression.
  • Understanding Notch-mediated EMT is crucial for developing new therapeutic strategies against breast cancer.
  • Further research into Notch's molecular mechanisms can provide new insights into tumorigenesis.
Keywords:
EMTNotchPI3K/Aktbreast cancercytokinehypoxiainvasionmetastasissignaling pathway

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