Endoscopic Management with a Novel Over-The-Scope Padlock Clip System

Area of Science:

• Gastroenterology and Endoscopy
• Surgical Devices
• Clinical Outcomes Research

Background:

• The Padlock clip is a new over-the-scope clip (OTSC) with a distinct design and application technique.
• Limited clinical data exists for this novel OTSC system.
• This study evaluates the initial clinical experience with the Padlock clip.

Purpose of the Study:

• To assess the safety and efficacy of the Padlock clip system in clinical practice.
• To report on the application of the Padlock clip for gastrointestinal bleeding and endoscopic full-thickness resection.

Main Methods:

• A prospective case series of 7 consecutive patients treated with the Padlock clip between September 2018 and June 2019.
• The Padlock clip was utilized for hemostasis in 4 patients with GI bleeding and for endoscopic full-thickness resection in 3 patients.
• Procedures were performed by an experienced endoscopist.

Main Results:

• All 7 patients achieved technical and clinical success.
• No complications or rebleeding were observed during a minimum 3-week follow-up.
• Patients were hospitalized for at least 48 hours post-procedure with no adverse events. Antiplatelet therapy was safely reinstated.

Conclusions:

• The Padlock clip is a safe, simple, and rapidly deployable novel OTSC.
• Full-thickness tissue closure facilitates early reinstatement of antiplatelet therapy when clinically indicated.
• The Padlock clip shows promise as an effective endoscopic closure device.