CYP2C19 genetic polymorphism in the Vietnamese population

Area of Science:

• Pharmacogenomics
• Human Genetics
• Drug Metabolism

Background:

• Genetic variations in CYP2C19 significantly impact drug metabolism and patient response.
• Previous studies on CYP2C19 genetic diversity in Vietnam are limited, particularly across diverse ethnic groups.

Purpose of the Study:

• To comprehensively investigate the genetic polymorphism of CYP2C19 in the Vietnamese population.
• To determine the allele frequencies of common CYP2C19 variants (*2, *3, *17) across different Vietnamese ethnic groups.

Main Methods:

• Sequencing of the promoter and all nine exons of CYP2C19 in 100 Vietnamese Kinh individuals.
• Analysis of CYP2C19 *2, *3, and *17 variants using RFLP-PCR in 275 individuals from four minority ethnic groups (Tay, Muong, H'Mong, Nung).

Main Results:

• In Kinh subjects, allele frequencies were: CYP2C19*1 (76%), *2 (20.5%), *3 (2.5%), and *17 (1%).
• CYP2C19*17 prevalence was lower in Vietnamese Kinh compared to Western Asia/Europe; CYP2C19*2 frequency was higher than in Western Asia/Europe.
• CYP2C19*2 allele frequency was significantly lower in Kinh compared to the other four ethnic minorities studied.

Conclusions:

• This study provides crucial data on CYP2C19 genetic polymorphism within the diverse Vietnamese population.
• Findings highlight ethnic variations in CYP2C19 allele frequencies, essential for personalized medicine and optimized drug therapy in Vietnam.