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Short-Duration Hypothermia Induction in Rats using Models for Studies examining Clinical Relevance and Mechanisms

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Is there a role for therapeutic hypothermia administration in term infants with mild neonatal encephalopathy?

Laura Perretta¹, Rachel Reed¹, Gail Ross¹

¹Department of Pediatrics Division of Newborn Medicine, Weill Cornell Medicine, NewYork Presbyterian Komansky Children's Hospital, 525 East 68th Street, New York, NY, 10065, USA.

Journal of Perinatology : Official Journal of the California Perinatal Association

|November 27, 2019

Objective:

Identifying term infants presenting with early mild neonatal encephalopathy (NE) as candidates for therapeutic hypothermia (TH) remains unclear. Study objectives were to characterize the neonatal clinical, magnetic resonance imaging (MRI), and longer-term outcome in infants with mild NE treated with TH.

Study Design:

Retrospective cohort study of infants admitted with mild or moderate NE treated with TH. Enrollment criteria included a sentinel event, severe acidosis, DR interventions, and low Apgar scores.

Results:

Infants with mild (n = 11) and moderate NE (n = 37) received TH. Mild NE findings included hyperalertness (64%), hypotonia (73%), high level sensory response (91%); 64% progressed to moderate NE. Infants with mild vs. moderate NE had less severe MRI changes (0 vs. 16%) and no cerebral palsy (CP) (0 vs. 13%).

Conclusions:

Outcomes were favorable with mild NE whereas four infants with moderate NE developed CP. A potential role for TH in this population requires further study.

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