The Association between Serum Testosterone and Risk Factors for Atherosclerosis

To study the associations between serum testosterone and risk factors for atherosclerosis in 119 men from general population.

Systolic pressure, body mass index (BMI), testosterone, fasting glucose, glucose tolerance test, apolipoprotein A-1 (ApoA-1), apolipoprotein B (ApoB), and ApoB/ApoA-1 ratio were assessed. Subjects classified into hypogonadal (testosterone ≤ 12 nmol/l), and eugonadal men (testosterone > 12 nmol/l).

BMI (28 vs. 26 kg/ m², p = 0.01), systolic pressure (129 vs. 123 mmHg, p = 0.03), fasting glucose (5.9 vs. 5.5 mmol/l, p = 0.03), ApoB (1.1 vs. 1.0 g/l, p = 0.03), and ApoB/ApoA-1 ratio (0.8 vs. 0.7, p = 0.03) were higher in hypogonadal compared to eugonadal men, respectively. In adjusted multivariate regression analysis model, testosterone showed negative associations with BMI (β = -1.832, p = 0.030, 95% CI = -3.485--0.180), fasting glucose (β = -0.394, p = 0.011, 95% CI = -0.696--0.091), glucose tolerance test (β = -0.957, p = 0.045, 95% CI = -1.892--0.022), ApoB (β = -0.157, p = 0.017, 95% CI = -0.286--0.029), and ApoB/ApoA-1 ratio (β = -0.118, p = 0.046, 95% CI = -0.234--0.002).

These results suggest an inverse association between testosterone levels and risk factors for atherosclerosis.