Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Model Approaches for Pharmacokinetic Data: Distributed Parameter Models01:06

Model Approaches for Pharmacokinetic Data: Distributed Parameter Models

211
Pharmacokinetic models are mathematical constructs that represent and predict the time course of drug concentrations in the body, providing meaningful pharmacokinetic parameters. These models are categorized into compartment, physiological, and distributed parameter models.
The distributed parameter models are specifically designed to account for variations and differences in some drug classes. This model is particularly useful for assessing regional concentrations of anticancer or...
211
Maxwell-Boltzmann Distribution: Problem Solving01:20

Maxwell-Boltzmann Distribution: Problem Solving

2.8K
Individual molecules in a gas move in random directions, but a gas containing numerous molecules has a predictable distribution of molecular speeds, which is known as the Maxwell-Boltzmann distribution, f(v).
This distribution function f(v) is defined by saying that the expected number N (v1,v2) of particles with speeds between v1 and v2 is given by
2.8K
Pharmacokinetic Models: Comparison and Selection Criterion01:26

Pharmacokinetic Models: Comparison and Selection Criterion

285
Physiological and compartmental models are valuable tools used in studying biological systems. These models rely on differential equations to maintain mass balance within the system, ensuring an accurate representation of the dynamic processes at play.
Physiological models take a detailed approach by considering specific molecular processes. They can predict drug distribution, metabolism, and elimination changes, providing a comprehensive understanding of how drugs interact with the body.
285
Column Efficiency: Rate Theory01:12

Column Efficiency: Rate Theory

835
The rate theory of chromatography provides quantitative insight into the shapes and widths of elution bands. These bands are based on the random-walk mechanism governing molecular migration within a column. The Gaussian profile of chromatographic bands arises from the cumulative effect of random molecular motions as they progress through the column.
During elution, a solute molecule experiences numerous transitions between stationary and mobile phases, exhibiting irregular residence times in...
835
One-Compartment Open Model: Wagner-Nelson and Loo Riegelman Method for ka Estimation01:24

One-Compartment Open Model: Wagner-Nelson and Loo Riegelman Method for ka Estimation

1.1K
This lesson introduces two critical methods in pharmacokinetics, the Wagner-Nelson and Loo-Riegelman methods, used for estimating the absorption rate constant (ka) for drugs administered via non-intravenous routes. The Wagner-Nelson method relates ka to the plasma concentration derived from the slope of a semilog percent unabsorbed time plot. However, it is limited to drugs with one-compartment kinetics and can be impacted by factors like gastrointestinal motility or enzymatic degradation.
On...
1.1K
Noncompartmental Analysis: Mean Transit, Absorption and Dissolution Time01:02

Noncompartmental Analysis: Mean Transit, Absorption and Dissolution Time

320
When drugs are administered extravascularly, a comprehensive evaluation through noncompartmental analysis becomes imperative. This analytical approach considers various parameters that play a crucial role in understanding the pharmacokinetics of these drugs.
One of the key parameters is the mean transit time (MTT), which refers to the total duration required for drug molecules to transit through the body. MTT is determined by calculating the ratio of the area under the moment curve to the area...
320

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Correction: Li et al. Gastrodin Ameliorates Cognitive Dysfunction in Vascular Dementia Rats by Suppressing Ferroptosis via the Regulation of the Nrf2/Keap1-GPx4 Signaling Pathway. <i>Molecules</i> 2022, <i>27</i>, 6311.

Molecules (Basel, Switzerland)·2026
Same author

Novel MRI-based scoring system for bone fragility evaluation in spinal disorders.

European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·2026
Same author

Diffusion MRI experimental design optimization for microstructure imaging.

Communications biology·2026
Same author

Added value of intravoxel incoherent motion histogram analysis in differentiating HER2-zero, HER2-low, and HER2-positive breast cancer.

La Radiologia medica·2026
Same author

Effects of formative-summative assessment weight configurations on evaluation validity and discriminatory power in landscape architecture planning and design courses.

Scientific reports·2026
Same author

Integrative transcriptomics and single-cell analysis unravel the senescence-reversing mechanism of quercetin in osteoarthritic chondrocytes.

Biochemical and biophysical research communications·2026
Same journal

A Multi-Head Attention Transformer Model for Wearable in Situ Fall Detection.

IEEE access : practical innovations, open solutions·2026
Same journal

Validating Single-Camera Pose Estimation Against Multi-Camera Motion Capture for Accessible Biomechanical Assessment.

IEEE access : practical innovations, open solutions·2026
Same journal

Learning to Diagnose Privately: DP-Powered LLMs for Radiology Report Classification.

IEEE access : practical innovations, open solutions·2026
Same journal

Radio-Frequency Toroid Susceptometry of Magnetic Nanoparticles: What Goes Around Comes Around.

IEEE access : practical innovations, open solutions·2026
Same journal

Cross-Architecture Knowledge Distillation for Histopathological Image Analysis.

IEEE access : practical innovations, open solutions·2026
Same journal

Mislabel Identification Using Transfer Learning-Based Ensemble Method.

IEEE access : practical innovations, open solutions·2026
See all related articles

Related Experiment Video

Updated: Jan 3, 2026

Synthesis of Cyclic Polymers and Characterization of Their Diffusive Motion in the Melt State at the Single Molecule Level
06:55

Synthesis of Cyclic Polymers and Characterization of Their Diffusive Motion in the Melt State at the Single Molecule Level

Published on: September 26, 2016

8.3K

Optimal transport for Gaussian mixture models.

Yongxin Chen1, Tryphon T Georgiou2, Allen Tannenbaum3

  • 1School of Aerospace Engineering, Georgia Institute of Technology, Atlanta, GA 30332, USA.

IEEE Access : Practical Innovations, Open Solutions
|November 27, 2019
PubMed
Summary
This summary is machine-generated.

We present a novel optimal mass transport framework for Gaussian mixture models, enabling natural comparisons and interpolations. This approach offers a weakly continuous topology for enhanced statistical inference with low computational cost.

Keywords:
Gaussian mixture modelsWasserstein metricoptimal mass transportstatistical signal analysis

More Related Videos

Image Processing Protocol for the Analysis of the Diffusion and Cluster Size of Membrane Receptors by Fluorescence Microscopy
12:15

Image Processing Protocol for the Analysis of the Diffusion and Cluster Size of Membrane Receptors by Fluorescence Microscopy

Published on: April 9, 2019

9.1K
A Workflow for Lipid Nanoparticle LNP Formulation Optimization using Designed Mixture-Process Experiments and Self-Validated Ensemble Models SVEM
13:54

A Workflow for Lipid Nanoparticle LNP Formulation Optimization using Designed Mixture-Process Experiments and Self-Validated Ensemble Models SVEM

Published on: August 18, 2023

5.7K

Related Experiment Videos

Last Updated: Jan 3, 2026

Synthesis of Cyclic Polymers and Characterization of Their Diffusive Motion in the Melt State at the Single Molecule Level
06:55

Synthesis of Cyclic Polymers and Characterization of Their Diffusive Motion in the Melt State at the Single Molecule Level

Published on: September 26, 2016

8.3K
Image Processing Protocol for the Analysis of the Diffusion and Cluster Size of Membrane Receptors by Fluorescence Microscopy
12:15

Image Processing Protocol for the Analysis of the Diffusion and Cluster Size of Membrane Receptors by Fluorescence Microscopy

Published on: April 9, 2019

9.1K
A Workflow for Lipid Nanoparticle LNP Formulation Optimization using Designed Mixture-Process Experiments and Self-Validated Ensemble Models SVEM
13:54

A Workflow for Lipid Nanoparticle LNP Formulation Optimization using Designed Mixture-Process Experiments and Self-Validated Ensemble Models SVEM

Published on: August 18, 2023

5.7K

Area of Science:

  • Computational statistics
  • Probability theory
  • Machine learning

Background:

  • Gaussian mixture models (GMMs) are fundamental in statistical inference.
  • Existing metrics for GMMs lack desirable properties like weak continuity.
  • Optimal mass transport (OMT) offers a powerful framework for comparing probability distributions.

Purpose of the Study:

  • Introduce an OMT framework specifically for the space of GMMs.
  • Equip the GMM space with the Wasserstein metric for a natural topology.
  • Develop methods for comparing, interpolating, and averaging GMMs.

Main Methods:

  • Treat GMMs as a submanifold within the space of probability densities.
  • Utilize the Wasserstein metric to define distances between GMMs.
  • Leverage properties of OMT for computational efficiency.

Main Results:

  • The Wasserstein metric provides weak continuity for GMMs, unlike other metrics.
  • The framework allows for natural interpolation and averaging of GMMs.
  • The proposed approach demonstrates low computational complexity.

Conclusions:

  • The OMT framework offers a principled and computationally efficient way to handle GMMs.
  • This work extends the applicability of OMT to complex statistical models.
  • The developed methods facilitate more robust statistical inference with GMMs.