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Published on: March 17, 2023
Moderate Frequency of Anti-Thyroglobulin Antibodies in the Early Phase of Subacute Thyroiditis
Eijun Nishihara1, Nobuyuki Amino1, Takumi Kudo1
1Kuma Hospital, Center for Excellence in Thyroid Care, Kobe, Japan.
Background:
Subacute thyroiditis is generally believed to be induced by viral infection, and little attention has been paid to anti-thyroid antibodies.
Objectives:
Our study aimed to assess the prevalence of anti-thyroid antibodies in patients with subacute thyroiditis.
Methods:
Anti-thyroglobulin (TgAb) and anti-thyroid peroxidase antibodies (TPOAb) were measured with 4 different immunoassay kits currently used in 40 patients in the early phase of subacute thyroiditis.
Results:
The proportion of samples positive for TgAb was 52.5 ± 13.7% (mean of 4 kits), which was significantly (p < 0.05) higher than that positive for TPOAb (15.6 ± 6.5%). The prevalence of positive TgAb alone (negative TPOAb) was also significantly higher than that of TPOAb alone (negative TgAb). TgAb titers decreased or disappeared within 4 months to 6 years in 6 patients.
Conclusions:
Patient samples were moderately positive for TgAb initially, but the titer decreased or disappeared afterwards in subacute thyroiditis.
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