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Alcohol Binge-Induced Cardiovascular Dysfunction Involves Endocannabinoid-CB1-R Signaling

Janos Paloczi1, Csaba Matyas1, Resat Cinar2

  • 1Laboratory of Cardiovascular Physiology and Tissue Injury, National Institutes of Health/National Institute on Alcohol Abuse and Alcoholism (NIAAA), Bethesda, Maryland.

JACC. Basic to Translational Science
|November 27, 2019
PubMed

Keywords:
2-AG, 2-arachidonyl glycerolAEA, anandamideCB1-R (CB1), cannabinoid 1 receptorCB2-R (CB2), cannabinoid 2 receptorEF, ejection fractionLV, left ventricleMAP, mean arterial pressureP-V, pressure-volumePRSW, preload recruitable stroke workTPR, total peripheral resistancebinge alcohol drinkingcannabinoidscontractilitydP/dtmax, maximal slope of pressure incrementendocannabinoids

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