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Related Concept Videos

Glaucoma: Overview01:25

Glaucoma: Overview

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Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
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Angle Closure Glaucoma: Treatment01:28

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Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
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In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
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Related Experiment Video

Updated: Jan 3, 2026

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts
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A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts

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[Acanthamoeba endophthalmitis-a case report].

J Pascha1, A Frings2, J Walochnik3

  • 1Medizinische Fakultät, Heinrich-Heine-Universität Düsseldorf, Düsseldorf, Deutschland.

Der Ophthalmologe : Zeitschrift Der Deutschen Ophthalmologischen Gesellschaft
|November 27, 2019
PubMed
Summary
This summary is machine-generated.

Acanthamoeba keratitis diagnosis is challenging and often mistaken for herpes keratitis. Voriconazole effectively treats acanthamoeba endophthalmitis when bacteria or fungi are absent.

Keywords:
HypopyonKeratitisKeratoplasticPTKVoriconazole

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Area of Science:

  • Ophthalmology
  • Infectious Diseases
  • Microbiology

Background:

  • Acanthamoeba keratitis (AK) diagnosis presents significant clinical challenges.
  • AK is frequently misdiagnosed as herpes keratitis.
  • Concurrent bacterial or fungal infections can delay AK diagnosis and treatment.

Observation:

  • Acanthamoeba detection in the anterior chamber is rare.
  • Endophthalmitis cases lacking bacterial or fungal identification warrant consideration of Acanthamoeba.

Findings:

  • Acanthamoeba should be a differential diagnosis for endophthalmitis without bacterial or fungal coinfection.
  • Local and systemic voriconazole administration demonstrates successful treatment of Acanthamoeba endophthalmitis.

Implications:

  • Early consideration of Acanthamoeba in specific endophthalmitis cases can improve patient outcomes.
  • Voriconazole offers a viable therapeutic option for Acanthamoeba endophthalmitis.