Related Experiment Video
Updated: Jan 3, 2026

Animal Models of Depression - Chronic Despair Model CDM
Published on: September 23, 2021
A New Component in the Mechanism of Regulation of Endogenous Depressive-Like States
T L Garibova1, T A Gudasheva2, S B Seredenin1
1Zakusov Research Institute of Pharmacology, Russian Academy of Medical Sciences, 125315, Moscow, Russia.
Abstract:
It was shown previously that cycloprolylglycine, an endogenous neuropeptide, is a positive AMPA receptor modulator and is able to increase the content of BDNF in neurons. In the present study, using the model of learned helplessness in rats, we showed that cycloprolylglycine at a dose of 1 mg/kg at subchronic intraperitoneal administration reduced the time of animal immobility to passive control values (from 167.6 to 83.6 s) on day 12 of the experiment. This indicates the presence of antidepressant-like activity. The results of the study allow us to consider cycloprolylglycine as a component in the physiological regulation of the depression-like state.
More Related Videos
Related Concept Videos
Depression: Overview
Depressive Disorders: Etiology
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
G-protein Coupled Receptors
Long-term Depression
Calcium Ion Concentration Mechanism
If over...
Long-term Depression
Regulation of Food Intake

