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The thyroid hormone (TH) plays a pivotal role in the intricate orchestration of physiological processes, exerting profound effects on development, metabolism, and homeostasis throughout different life stages.
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Obesity significantly alters the pharmacokinetic processes of drug absorption and distribution, presenting unique challenges in medical treatment. The increased fat tissue and decreased lean muscle in obese individuals can significantly affect how drugs are absorbed into the body and distributed across different tissues. This alteration can lead to variances in the effectiveness and safety of medications, necessitating adjustments in dosing or drug selection for obese patients.One notable...
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Multidisciplinary Approach to Obesity Management: A Case Report
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Levothyroxine supplementation for obesity-associated thyroid dysfunction in children: a prospective, randomized, case

Sugantha Kumar1, Devi Dayal1, Savita Attri1

  • 1Department of Pediatrics, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Pediatric Endocrinology, Diabetes, and Metabolism
|November 27, 2019
PubMed
Summary

Adding levothyroxine to weight management for obese children with thyroid dysfunction did not improve BMI or lipid profiles. This treatment offers no benefit and should not be prescribed in such cases.

Keywords:
childrenisolated hyperthyrotropinemialevothyroxineobesity associated thyroid dysfunctionsubclinical hypothyroidismexogenous obesity

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Area of Science:

  • Pediatric Endocrinology
  • Obesity Management
  • Thyroid Disorders

Background:

  • Thyroid dysfunction in children with simple obesity (SO) presents a controversial treatment landscape.
  • Isolated hyperthyrotropinemia is observed in obese children.

Purpose of the Study:

  • To evaluate the efficacy of low-dose levothyroxine in addition to weight management for children with obesity-associated thyroid dysfunction.

Main Methods:

  • A randomized trial involving 51 children (aged 6-12 years) with SO and elevated TSH.
  • Participants received either standard weight management or weight management plus low-dose levothyroxine for 6 months.
  • Outcomes measured included BMI Z-scores, TSH, T3, T4, and lipid profiles.

Main Results:

  • Both groups showed a decrease in BMI Z-scores and TSH levels over 6 months.
  • The reduction in BMI Z-scores and TSH was comparable between the levothyroxine and control groups.
  • No significant differences were observed in lipid profiles between the two groups.

Conclusions:

  • Low-dose levothyroxine offers no additional benefit for BMI reduction or improvement of thyroid and lipid profiles in children with obesity and thyroid dysfunction.
  • Levothyroxine should not be routinely prescribed for this patient population.