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Adipokines as key players in β cell function and failure
Nicolás Gómez-Banoy1, James C Lo1
1Weill Center for Metabolic Health and Division of Cardiology, Department of Medicine, Weill Cornell Medicine, New York, NY 10021, U.S.A.
Clinical Science (London, England : 1979)
|November 27, 2019
Summary
Adipokines, secreted by adipose tissue, significantly influence pancreatic beta cell function and survival. Understanding these metabolic orchestrators offers therapeutic potential for diabetes and related diseases.
Area of Science:
- Metabolic endocrinology
- Cell biology
- Diabetes research
Background:
- Obesity prevalence drives interest in adipose tissue (AT) as a metabolic regulator.
- AT functions as an endocrine organ, secreting adipokines.
- Adipokines impact whole-body metabolism and target pancreatic beta cells.
Purpose of the Study:
- To review how adipokines affect pancreatic beta cell function.
- To examine adipokine impact on beta cell survival in diabetes.
- To discuss therapeutic potential of novel adipocyte-specific factors.
Main Methods:
- Literature review of adipokine research.
- Analysis of adipokine mechanisms on pancreatic beta cells.
- Focus on classic and novel adipokines.
Main Results:
- Adipokines are key regulators of pancreatic beta cell function.
- Adipokines influence beta cell survival in metabolic disease.
- Novel adipokines show promise for therapeutic intervention.
Conclusions:
- Adipokines play a critical role in the adipose-pancreatic beta cell axis.
- Targeting adipokines may offer new strategies for managing diabetes.
- Further research into novel adipokines is warranted.
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