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An Experimental Paradigm for the Prediction of Post-Operative Pain (PPOP)
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Benefits of continuous infusion epidural analgesia throughout vaginal delivery

M L Johnsrud1, P O Dale, B Løvland

  • 1Vestfold Central Hospital, Department of Obstetrics and Gynecology, Tønsberg, Norway.

Acta Obstetricia Et Gynecologica Scandinavica
|January 1, 1988
PubMed

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Epidural anesthetics are administered in the fat-filled epidural space, the outermost part of the spinal canal. This technique is commonly employed for pain management and anesthesia during lower abdomen and pelvis surgeries or labor and delivery.
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Intravenous anesthetics are drugs administered parenterally to induce anesthesia or sedation. Propofol is a widely used agent formulated as a 1% emulsion in soybean oil, glycerol, and egg phosphatide. It induces rapid anesthesia primarily due to its rapid distribution from the bloodstream to target tissues and is metabolized in the liver. However, it can cause significant pain on injection and hypertriglyceridemia. Fospropofol, a water-based prodrug of propofol, lacks these adverse effects.
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The parenteral route is a critical method of drug administration. It delivers compounds directly into the systemic circulation and bypasses the gastrointestinal tract. This approach is particularly advantageous for drugs that exhibit poor absorption or instability when administered orally.
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