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Pregnancy in a 50-year-old.

P Helm¹, B Ovlisen

¹Department of Gynecology and Obstetrics, Central Hospital, Hillerød, Denmark.

Acta Obstetricia Et Gynecologica Scandinavica

|January 1, 1988

Summary

Pregnancy in women over 45 carries significant risks. A 50-year-old woman experienced a late-term fetal demise due to Edwards' syndrome, highlighting the importance of advanced maternal age considerations.

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Area of Science:

Perinatology
Medical Genetics

Background:

Pregnancy in advanced maternal age (AMA), typically defined as 35 years or older, is associated with increased risks for both the mother and fetus.
Maternal age over 45 is considered high-risk due to a higher prevalence of chromosomal abnormalities and other pregnancy complications.

Observation:

A 50-year-old woman presented with suspected abdominal tumor.
Clinical examination and ultrasonography confirmed a viable fetus at 24.2 weeks of gestation.
Amniocentesis diagnosed trisomy 18 (Edwards' syndrome).

Findings:

The fetus experienced spontaneous demise at 34 weeks gestation.
A cesarean section resulted in the delivery of a stillborn male infant weighing 770g.

Implications:

This case underscores the elevated risks of pregnancy in women over 45, particularly concerning chromosomal abnormalities like Edwards' syndrome.
It emphasizes the need for comprehensive prenatal screening and counseling for advanced maternal age pregnancies.
The spontaneous fetal demise highlights the potential for adverse outcomes even with careful monitoring.

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