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Development of apical-surface structures of mouse otic placode
T Kikuchi1, A Tonosaki, T Takasaka
1Department of Otorhinolaryngology, Tohoku University School of Medicine, Sendai, Japan.
Acta Oto-Laryngologica
|September 1, 1988
Summary
Early embryonic otic placodes feature primitive 9+0 cilia and developing microvilli. These structures resemble adult vestibular kinocilia, suggesting a shared evolutionary origin in early development.
Area of Science:
- Developmental Biology
- Cell Biology
- Embryology
Background:
- The apical surface of early embryonic cells exhibits unique structures like cilia and microvilli.
- Understanding these structures is crucial for deciphering developmental processes and cell differentiation.
Purpose of the Study:
- To investigate the morphology and development of apical surface structures in early embryonic otic placodes.
- To compare these embryonic structures with those found in adult vestibular sensory cells.
Main Methods:
- Observation of 8.0-11.0 gestation-day embryos using microscopy.
- Analysis of apical surface structures, including cilia and microvilli, on otic placode cells.
- Comparison of embryonic cilia with kinocilia from adult vestibular sensory cells.
Main Results:
- Primitive 9+0 cilia, lacking central fibres, were observed on early otic placode cells.
- Microvilli increased in length and density during otic placode invagination.
- Apical surface structures showed marked regional differences in later embryonic stages.
- Adult vestibular kinocilia lacked central fibres, similar to embryonic otic placode cilia.
Conclusions:
- Embryonic otic placode cilia share structural similarities with adult vestibular kinocilia.
- Vestibular kinocilia may be descendants of primordial cilia found on early ectodermal cells.
- These findings shed light on the evolutionary origins of sensory structures in the inner ear.