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Systematically Prioritizing Candidates in Genome-Based Drug Repurposing.

Anup P Challa1, Robert R Lavieri1, Judith T Lewis1

  • 1Vanderbilt Institute for Clinical and Translational Research, Vanderbilt University Medical Center, Nashville, Tennessee.

Assay and Drug Development Technologies
|November 27, 2019
PubMed
Summary
This summary is machine-generated.

This study identifies practical precision drug repurposing opportunities by integrating drug data with genomic information. It presents 14 promising candidates for new disease treatments, ready for clinical trials.

Keywords:
drug repurposinggenomicsinformaticsphenome-wide association study (PheWAS)precision medicine

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Area of Science:

  • Pharmacogenomics
  • Drug Discovery
  • Translational Medicine

Background:

  • Drug repurposing offers a faster route to new treatments by using existing medications for novel indications.
  • Integrating genomic data with drug information is crucial for precision medicine approaches.
  • Large-scale biobanks linked to electronic health records are valuable resources for drug repurposing research.

Purpose of the Study:

  • To define the scope of practical precision drug repurposing.
  • To develop a method for prioritizing drug repurposing candidates using integrated data sources.
  • To identify potential drug repurposing candidates for clinical investigation.

Main Methods:

  • Utilized DrugBank, a pharmacological database, and BioVU, a de-identified DNA repository with electronic health records.
  • Integrated pharmacodynamic and marketing data from DrugBank with genomic quality control thresholds from BioVU.
  • Identified "target-action pairs" by combining drug information with target genomics.

Main Results:

  • Identified approximately 230 "target-action pairs" representing practical genomic drug repurposing opportunities.
  • Developed a pipeline of 14 drug repurposing candidates across 7 disease areas.
  • These candidates demonstrate high potential for initiating randomized controlled trials.

Conclusions:

  • The study presents a systematic approach to genomic drug repurposing.
  • Identified candidates are poised for further clinical validation and development.
  • This work facilitates the advancement of precision medicine through drug repurposing.