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Author Spotlight: Modeling an Aspect of Preeclampsia in Female Mice Using Hypoxic Human Placenta-Derived Small Extracellular Vesicles
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Author Spotlight: Modeling an Aspect of Preeclampsia in Female Mice Using Hypoxic Human Placenta-Derived Small Extracellular Vesicles

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Hepatic Complications in Preeclampsia

Suchitra Chandrasekaran1, Rebecca Simon

  • 1Department of Obstetrics and Gynecology, University of Washington, Seattle, Washington.

Clinical Obstetrics and Gynecology
|November 27, 2019
PubMed

Insights

Preeclampsia with severe features and HELLP syndrome can cause serious liver complications. This review covers hepatic function, diagnosis, management, and genetic factors in preeclampsia and HELLP syndrome.

Area of Science:

  • Obstetrics and Gynecology
  • Maternal-Fetal Medicine
  • Hepatology

Background:

  • Preeclampsia with severe features and HELLP syndrome present significant risks for maternal hepatic complications.
  • Hepatic dysfunction is a critical aspect of preeclampsia, impacting both short-term and long-term maternal health.

Purpose of the Study:

  • To comprehensively review the hepatic aspects of preeclampsia and HELLP syndrome.
  • To discuss the pathophysiology, diagnosis, management, and genetic predispositions related to hepatic abnormalities in these conditions.

Main Methods:

  • Literature review focusing on hepatic function in normal pregnancy and during preeclampsia.
  • Analysis of diagnostic criteria, management strategies, and prognostic indicators for preeclampsia and HELLP syndrome.
  • Exploration of genetic factors and differential diagnosis of HELLP syndrome.

Main Results:

  • Detailed examination of normal hepatic physiology during pregnancy.
  • Pathophysiological mechanisms linking preeclampsia to hepatic dysfunction.
  • Evaluation of biomarkers for diagnosis and prognosis, and management of subcapsular hematoma.

Conclusions:

  • Hepatic complications in preeclampsia and HELLP syndrome require thorough understanding for optimal maternal care.
  • Biomarkers and genetic factors play a role in the diagnosis and predisposition to these conditions.
  • Effective management strategies are crucial for improving maternal outcomes.

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