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Related Concept Videos

lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

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In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
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lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

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Types of RNA01:20

Types of RNA

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Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA Performs Diverse...
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Types of RNA01:23

Types of RNA

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Overview
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA...
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MicroRNAs01:22

MicroRNAs

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MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After...
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MicroRNAs01:22

MicroRNAs

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MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
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Related Experiment Video

Updated: Jan 3, 2026

Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells
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Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells

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Non-coding RNA and lung cancer progression.

Afeez Adekunle Ishola1,2, Anita Silas La'ah1,2, Hung Dinh Le2

  • 1Division of Basic Research, Department of Medical Research, Taipei Veterans General Hospital, Taipei, Taiwan, ROC.

Journal of the Chinese Medical Association : JCMA
|November 27, 2019
PubMed
Summary
This summary is machine-generated.

Noncoding RNAs, including microRNAs, long noncoding RNAs, and circular RNAs, play critical roles in lung cancer development and progression. Understanding these molecules offers new avenues for lung cancer treatment.

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Last Updated: Jan 3, 2026

Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells
07:23

Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells

Published on: May 30, 2025

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Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Lung cancer remains a leading global cause of death with poor survival rates.
  • While smoking is a major risk factor, non-smokers also develop lung cancer, indicating genetic and epigenetic factors.
  • Noncoding RNAs (ncRNAs), including microRNAs (miRNAs), long ncRNAs (lncRNAs), and circular RNAs (circRNAs), are increasingly recognized for their roles in lung cancer.

Purpose of the Study:

  • To review the roles of key ncRNAs (miRNAs, lncRNAs, circRNAs) in lung cancer pathogenesis and progression.
  • To discuss the paracrine effects of exosomal ncRNAs in lung cancer.
  • To highlight the therapeutic potential of ncRNAs for improved lung cancer treatment.

Main Methods:

  • Literature review focusing on the functions of miRNAs, lncRNAs, and circRNAs in lung cancer.
  • Analysis of existing research on gene modulation by these ncRNAs.
  • Examination of studies on exosomal ncRNAs and their impact.

Main Results:

  • miRNAs, lncRNAs, and circRNAs are integral components of gene regulatory networks in lung cancer.
  • These ncRNAs interact to control gene expression, influencing cancer development.
  • Exosomal ncRNAs exhibit paracrine effects, contributing to lung cancer progression.

Conclusions:

  • ncRNAs are crucial players in lung cancer biology.
  • The intricate interactions between different ncRNAs offer insights into disease mechanisms.
  • Targeting ncRNAs presents a promising strategy for future lung cancer therapies.