Moxibustion for treating patients with hyperlipidemia: A systematic review and meta-analysis protocol
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Qin Yao1, Xinyue Zhang, Yueping Huang
1Beijing University of Chinese Medicine, Beijing, China.
Insights
Moxibustion therapy shows promise for managing hyperlipidemia by potentially lowering blood lipid levels. This systematic review assesses its effectiveness and safety for patients with high cholesterol.
Area of Science:
- Integrative Medicine
- Cardiovascular Health
- Traditional Chinese Medicine
Background:
- Hyperlipidemia is a primary driver of atherosclerosis and increases the risk of cardiovascular and cerebrovascular diseases.
- Moxibustion therapy is increasingly recognized for its potential in managing hyperlipidemia.
- This systematic review aims to evaluate the efficacy and safety of moxibustion for hyperlipidemia.
Purpose of the Study:
- To systematically review and assess the effectiveness of moxibustion therapy in treating hyperlipidemia.
- To evaluate the safety profile of moxibustion as an intervention for hyperlipidemia.
- To synthesize current evidence on moxibustion's impact on blood lipid levels.
Main Methods:
- Comprehensive electronic searches of multiple databases (e.g., PubMed, EMBASE, CNKI) will be conducted.
- Two independent reviewers will perform study selection, data extraction, and quality assessment.
- Primary outcomes include changes in LDL-C, TC, TG, and HDL-C levels; secondary outcomes involve quality of life, long-term effects, and safety.
Main Results:
- This systematic review will present a comprehensive analysis of existing evidence.
- The findings will detail the effectiveness of moxibustion in managing hyperlipidemia.
- Safety data and potential adverse effects will be thoroughly examined.
Conclusions:
- The review will provide evidence-based conclusions on the efficacy of moxibustion for hyperlipidemia.
- It will help determine if moxibustion is a safe and effective treatment option.
- Findings will inform clinical practice and future research directions.
Background:
Hyperlipidemia has been a root cause of atherosclerosis, which leads to a high risk to serious cardio-cerebrovascular disease. Many trials have reported that moxibustion therapy is effective in lowering blood lipid levels when treating hyperlipidemia. The aim of this systematic review is to assess the effectiveness and safety of moxibustion therapy for hyperlipidemia.
Methods:
Two reviewers will electronically search the following databases: the Cochrane Central Register of Controlled Trials (CENTRAL); PubMed; EMBASE; China National Knowledge Infrastructure (CNKI); Chinese Biomedical Literature Database (CBM); Chinese Scientific Journal Database (VIP database); and Wan-Fang Database from the inception, without restriction of publication status and languages. Additional searching including researches in progress, the reference lists and the citation lists of identified publications. Study selection, data extraction, and assessment of study quality will be performed independently by 2 reviewers. Changes of blood lipid levels from baseline to the end of the treatment, including low-density lipoprotein cholesterol (LDL-C) level, total cholesterol (TC) level, triglycerides (TG) level and high-density lipoprotein cholesterol (HDL-C) level will be assessed as the primary outcomes. Quality of life, long-term effect and safety will be evaluated as secondary outcomes. If it is appropriate for a meta-analysis, RevMan 5.3 statistical software will be used; otherwise, a descriptive analysis will be conducted. Data will be synthesized by either the fixed-effects or random-effects model according to a heterogeneity test. The results will be presented as risk ratio (RR) with 95% confidence intervals (CIs) for dichotomous data and weight mean difference (WMD) or standard mean difference (SMD) 95% CIs for continuous data.
Results:
This study will provide a comprehensive review of the available evidence for the treatment of moxibustion with hyperlipidemia.
Conclusions:
The conclusions of our study will provide an evidence to judge whether moxibustion is an effective and safe intervention for patients with hyperlipidemia.
Ethics And Dissemination:
This systematic review will be disseminated in a peer-reviewed journal or presented at relevant conferences. It is not necessary for a formal ethical approval because the data are not individualized.
Trial Registration Number:
PROSPERO CRD42019130545.
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