Analysis of intracranial pressure waveform during infusion test

An analysis of intracranial pressure (ICP), based on an examination of the temporary correlation between the changes in amplitude of the pulse wave and the mean ICP level, is presented. The paper contains a discussion of the preliminary results of the method when applied to the analysis of ICP as monitored during infusion tests in a group of 24 children. Infusion of a certain volume of CSF is a good example of an uncompensated volume process, introduced externally into the intracranial space. Results allow an interpretation of the short term correlation coefficient RAP (correlation coefficient between ICP and variations of the amplitude of fundamental component of the pulse wave AMP), as a steady state index. According to this interpretation, the presented analysis enables the observation of a loss of equilibrium during the test. Other phenomena can also be observed, for instance a recovery to equilibrium after the test, nonlinearities of amplitude-pressure relationship, vasomotor reflexes etc.