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LmjMAPK10 offers protection against Leishmania donovani infection

Sunil Kumar1, Shubhranshu Zutshi1, Ashok Patidar1

  • 1National Centre for Cell Science, Pune, India.

Parasite Immunology
|November 27, 2019
PubMed
Abstract

Insights

DNA vaccination using Leishmania major-derived MAPK10 (mitogen-activated protein kinase 10) shows cross-protection against Leishmania donovani infection, reducing parasite burden and enhancing host immunity.

Area of Science:

  • Immunology
  • Parasitology
  • Molecular Biology

Background:

  • Leishmania major and Leishmania donovani are parasitic protozoa causing different forms of leishmaniasis.
  • Mitogen-activated protein kinases (MAPKs) are crucial in parasitic organisms.
  • MAPK10 is a specific MAPK identified in Leishmania major.
Keywords:
Leishmania donovaniMAPK10anti-leishmanial vaccinehost-protective immune responsevisceral leishmaniasis

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