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Identification of TL+ thymocytes with different Lyt phenotypes
The surface antigenic phenotype of BALB/c thymocytes has been analyzed by sequential cytotoxic treatment with Lyt-1.2, Lyt-2.2 and TL.2 antisera plus complement. Two new minor subpopulations with TL+Lyt-1+2- and TL+Lyt-1-2+ phenotypes have been identified providing direct evidence for the heterogeneity of the Lyt phenotype among the TL-positive supopulation of thymocytes. This finding suggests that differentiation pathways of Lyt subsets of T cells are more complex than originally proposed and that commitment to separate lines of differentiation may occur already at the level of immature, cortical thymocytes.
The surface antigenic phenotype of BALB/c thymocytes has been analyzed by sequential cytotoxic treatment with Lyt-1.2, Lyt-2.2 and TL.2 antisera plus complement. Two new minor subpopulations with TL+Lyt-1+2- and TL+Lyt-1-2+ phenotypes have been identified providing direct evidence for the heterogeneity of the Lyt phenotype among the TL-positive supopulation of thymocytes. This finding suggests that differentiation pathways of Lyt subsets of T cells are more complex than originally proposed and that commitment to separate lines of differentiation may occur already at the level of immature, cortical thymocytes.