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Generation of Hypoparathyroid Rats via Carbon-Nanoparticle-Assisted Parathyroidectomy
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Elevated parathyroid hormone levels and cognitive function: A systematic review.

Wen Jiang1, Cheng-Yang Hu1, Feng-Li Li1

  • 1Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei 230032, China.

Archives of Gerontology and Geriatrics
|November 27, 2019
PubMed
Summary
This summary is machine-generated.

Elevated parathyroid hormone (PTH) levels show a weak and inconsistent association with cognitive function, including memory and executive function. More high-quality research is needed to confirm any potential links.

Keywords:
Cognitive functionParathyroid hormoneSystematic review

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Area of Science:

  • Endocrinology
  • Neurology
  • Gerontology

Background:

  • Parathyroid hormone (PTH) plays a crucial role in calcium homeostasis.
  • Emerging evidence suggests potential links between hormonal imbalances and cognitive decline.
  • Understanding the relationship between elevated PTH and cognitive function is important for aging populations.

Purpose of the Study:

  • To systematically review and estimate the association between elevated parathyroid hormone (PTH) levels and cognitive function.
  • To assess the quality of existing studies investigating this relationship.

Main Methods:

  • A systematic review of ten papers published up to October 31, 2018.
  • Study quality was evaluated using the Downs and Black checklist.

Main Results:

  • A low volume of data exists on elevated PTH and cognitive impairment.
  • Study quality varied significantly, from poor (37%) to good (76%).
  • Mixed evidence suggests a potential link between elevated PTH and decreased Mini-Mental State Examination (MMSE) scores, but results for other cognitive domains like executive function and memory were inconsistent. Associations with Alzheimer's disease and vascular dementia were also weakly supported.

Conclusions:

  • The current evidence for an association between elevated PTH levels and cognitive function is generally weak and inconsistent.
  • Further research with improved methodological quality is necessary to establish a definitive link.