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Related Experiment Video

Updated: Jan 3, 2026

A Component-resolved Diagnostic Approach for a Study on Grass Pollen Allergens in Chinese Southerners with Allergic Rhinitis and/or Asthma

A Component-resolved Diagnostic Approach for a Study on Grass Pollen Allergens in Chinese Southerners with Allergic Rhinitis and/or Asthma

Published on: June 4, 2017

Identifying Potential Co-Sensitization and Cross-Reactivity Patterns Based on Component-Resolved Diagnosis.

Zhifeng Huang¹, Xiangwei Zou¹, Hao Chen¹

¹Department of Allergy and Clinical Immunology, Guangzhou Institute of Respiratory health, State Key Laboratory of Respiratory Disease, National Clinical Research Center of Respiratory Disease, First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.

International Archives of Allergy and Immunology

|November 27, 2019

Summary

Component-Resolved Diagnosis (CRD) identified primary sensitizing allergens like Der p 1 and Der f 1 in mite-allergic patients. This method reveals co-sensitization and cross-reactivity patterns, aiding in personalized allergy management.

Keywords:

Allergy rhinitis Asthma Co-Sensitization Component-resolved diagnosis Cross-Reactivity Dust mite sensitized

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Last Updated: Jan 3, 2026

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Application of Biochip Microfluidic Technology to Detect Serum Allergen-specific Immunoglobulin E sIgE

Application of Biochip Microfluidic Technology to Detect Serum Allergen-specific Immunoglobulin E sIgE

Published on: April 21, 2019

Area of Science:

Allergology and Immunology
Molecular Biology
Epidemiology

Background:

Component-Resolved Diagnosis (CRD) is crucial for understanding specific immunoglobulin E (IgE) sensitization profiles.
CRD differentiates primary sensitization from cross-reactivity, especially in polysensitized individuals.
Identifying allergen component sensitization aids in assessing allergy risks.

Purpose of the Study:

To investigate co-sensitization and cross-reactivity among 17 allergen components in mite-sensitized respiratory allergy patients.
To describe potential associations between allergen components in Guangdong Province, China.
To utilize Component-Resolved Diagnosis (CRD) for detailed sensitization profiling.

Main Methods:

Recruited 432 patients with mite-sensitized respiratory allergic diseases.
Employed the EUROIMMUN system for serum-specific IgE testing of 17 allergen components.
Utilized hierarchical cluster and optimal scale analysis for sensitization pattern identification.

Main Results:

Der p 1, Der f 2, Der f 1, Der p 2, and Der p 23 were the most frequently sensitized components.
Hierarchical clustering revealed 5 distinct sensitization clusters with high co-sensitization and cross-reactivity within clusters.
Sensitization profiles remained consistent across different patient demographics and disease types.

Conclusions:

CRD provides valuable epidemiological data on allergen components causing allergic symptoms.
Der p 1, Der p 2, Der p 23, Der f 1, and Der f 2 were identified as primary sensitizing components.
CRD facilitates the identification of potential allergen associations, guiding clinicians to consider related allergens for comprehensive patient care.