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Hyperpigmentation as a cutaneous manifestation of fungal sepsis in neonates: Case series report

P Prabhakar1, P Batra1, C Verma1

  • 1Department of Pediatrics, University College of Medical Sciences and Guru Teg Bahadur Hospital, Delhi, India.

Journal of Neonatal-Perinatal Medicine
|November 28, 2019
PubMed

Insights

Invasive fungal infections, particularly candidiasis, are a serious concern for premature infants. This study highlights cutaneous hyperpigmentation as a potential sign of systemic candidiasis in neonates.

Area of Science:

  • Neonatal Intensive Care
  • Infectious Diseases
  • Dermatology

Background:

  • Invasive fungal infections are increasingly recognized in very and extremely low birth weight infants.
  • Candidiasis is a leading cause of late-onset sepsis in neonates, carrying significant mortality.
  • Risk factors include extreme prematurity, central venous catheters, prolonged antibiotic use, and parenteral nutrition.

Purpose of the Study:

  • To investigate cutaneous manifestations of systemic candidiasis in neonates.
  • To report a series of cases where hyperpigmentation indicated invasive fungal infection.

Main Methods:

  • Case series reporting on four neonates with systemic candidiasis.
  • Clinical observation and documentation of cutaneous findings.

Main Results:

  • Four cases of neonatal candidiasis presented with cutaneous hyperpigmentation.
  • This finding suggests a link between skin changes and systemic fungal infection.

Conclusions:

  • Cutaneous hyperpigmentation can be an indicator of systemic candidiasis in high-risk neonates.
  • Early recognition of this dermatological sign may aid in timely diagnosis and treatment of invasive fungal infections.
Keywords:
Cutaneous hyperpigmentationcandidiasisfungemianeonates

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