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Bacteriotherapy in Breast Cancer
Atieh Yaghoubi1,2, Majid Khazaei3, Seyed Mahdi Hasanian4
1Antimicrobial Resistance Research Center, Bu-Ali Research Institute, Mashhad University of Medical Sciences, Mashhad 91387-35499, Iran.
International Journal of Molecular Sciences
|November 28, 2019
Summary
Exploring novel breast cancer treatments, this review highlights bacteria
Area of Science:
- Oncology
- Microbiology
- Biotechnology
Background:
- Breast cancer remains a leading cause of mortality in women globally.
- Conventional treatments like chemotherapy face challenges in efficacy.
- Emerging research suggests bacteria may offer novel therapeutic avenues for breast cancer.
Purpose of the Study:
- To review the potential of bacteria and their products in treating breast cancer.
- To explore the therapeutic applications of bacterial peptides, bacteriocins, and toxins.
- To discuss the role of genetically modified bacteria in cancer therapy.
Main Methods:
- Literature review of studies on bacterial therapy for breast cancer.
- Analysis of research on bacterial products (peptides, bacteriocins, toxins).
- Examination of genetically engineered bacteria for targeted cancer treatment.
Main Results:
- Some bacteria exhibit selective toxicity towards cancer cells with low impact on normal cells.
- Live, attenuated, or genetically modified bacteria can colonize tumors and inhibit growth.
- Bacterial products show promise as anti-cancer agents.
Conclusions:
- Bacteria and their derivatives represent a promising area for developing new breast cancer treatments.
- Genetic engineering can enhance bacterial therapy efficacy and safety.
- Further research into bacterial-based strategies is warranted for improved patient outcomes.
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