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Aspirin-induced asthma in children
1Servicio de Alergia, Hospital Infantil de la Vall d'Hebron. Universidad Autonoma, Barcelona, Spain.
Allergologia Et Immunopathologia
|May 1, 1988
Summary
Aspirin-induced asthma is common in children, affecting up to 28% of pediatric asthmatics. Diagnosis requires oral provocation tests to identify sensitivities to aspirin and other substances.
Area of Science:
- Pediatric Pulmonology
- Clinical Immunology
- Pharmacology
Background:
- Bronchospasm induced by acetyl salicylic acid (aspirin) has been recognized since 1919.
- Recent studies suggest a higher incidence of aspirin-induced asthma in children (13-28%) than previously thought.
- This highlights the need for further investigation into its prevalence and management in pediatric populations.
Purpose of the Study:
- To investigate the incidence and clinical presentation of aspirin-induced asthma in pediatric patients.
- To evaluate the utility of oral provocation testing in diagnosing aspirin sensitivity and identifying cross-reactivity.
- To assess sensitivity to other non-steroidal anti-inflammatory drugs (NSAIDs) and food additives.
Main Methods:
- Case study of 4 pediatric patients (2 atopic, 2 non-atopic) with suspected aspirin-induced asthma.
- Detailed clinical history collection.
- Oral provocation tests with acetyl salicylic acid, various NSAIDs, and food additives (tartrazine, red coccine).
Main Results:
- All 4 patients showed a positive oral provocation test to acetyl salicylic acid.
- Two patients had negative provocation tests to NSAIDs and additives.
- The remaining two patients exhibited sensitivity to specific additives, including tartrazine and red coccine, and NSAIDs like mefenamic acid and benorylate.
Conclusions:
- Aspirin-induced asthma is a significant concern in pediatric patients.
- Oral provocation testing is crucial for accurate diagnosis of aspirin sensitivity.
- Identifying cross-reactivity to NSAIDs and food additives is essential for comprehensive patient management.