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Related Experiment Video

Updated: Jan 3, 2026

Protocols for Investigating the Host-tissue Distribution, Transmission-mode, and Effect on the Host Fitness of a Densovirus in the Cotton Bollworm
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Evidence for densovirus integrations into tapeworm genomes.

Michaela Herz1, Klaus Brehm2,3

  • 1Institut für Hygiene und Mikrobiologie, Universität Würzburg, Josef-Schneider-Str 2/E1, 97080, Würzburg, Germany.

Parasites & Vectors
|November 28, 2019
PubMed
Summary

Tapeworms integrate densovirus elements, offering insights into mobile genetic element silencing. This widespread DNA virus integration in tapeworm genomes provides new avenues for genetic manipulation research.

Keywords:
DensovirusEchinococcosisEchinococcusEpigeneticGene silencingMobile genetic elementParvovirusStem cell

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Area of Science:

  • Parasitology
  • Molecular Biology
  • Genomics

Background:

  • Tapeworms (Cestoda) lack a canonical piRNA pathway for regulating mobile genetic elements (MGEs).
  • Understanding tapeworm transposon activity is crucial for investigating their gene silencing mechanisms.
  • Information on tapeworm transposons remains limited, hindering research.

Purpose of the Study:

  • To investigate the presence and characteristics of densovirus-related sequences in tapeworm genomes.
  • To explore the transcriptional activity of these integrated densovirus elements.
  • To assess the potential of densovirus elements for genetic manipulation in tapeworms.

Main Methods:

  • Bioinformatic analysis of tapeworm genomes for densovirus sequences.
  • Mapping RNA-Seq datasets to the Echinococcus multilocularis genome to quantify gene expression.
  • RT-qPCR and sequencing to analyze transcription of densovirus loci.

Main Results:

  • Densovirus-related elements were identified across multiple tapeworm species.
  • Over 20 densovirus loci, encoding viral proteins, were found in the Echinococcus multilocularis genome.
  • While some loci were transcribed, particularly in stem cells, most were silent, indicating potential gene silencing.

Conclusions:

  • Widespread integration of densovirus DNA viruses into cestode genomes is reported for the first time.
  • The limited transcriptional activity of integrated densovirus sites is relevant for studying tapeworm gene silencing.
  • Densovirus-based vectors show promise for the genetic manipulation of tapeworms.